Chemical Engineering April 2022 - 19

kind. One of the
challenges will
be the capacity
to manufacture
more
bioreacUpside
Foods
FIGURE 4. A view from the control room of Upside Foods' Engineering, Production
and Innovation Center in Emeryville, Calif.
Innovation Biosolutions at Wacker.
" We also believe that as the industry
grows, we will need to build up
a supply chain for these compounds
that satisfies the food industry's requirements
and regulations. "
Scaleup challenges
Supply chain issues may also hinder
progress as companies complete their
pilot phase and look to build commercial
plants. Scaleup will require good
planning in advance, says B&V's Zistors.
" There is
a certain lead
time for a largescale
piece of
equipment, and
it might take a
year or even longer
before you
get it, " explains
Ziskind. " Think of all the innovation
and the movement in this space. You
could order a piece of equipment
today to be delivered in 2023, but the
way things change, it might not be the
right size or isn't the right technology
by the time it arrives. Companies need
to be forward-focused, " he says.
Nevertheless, " every basic technology
needed for cultivated meat
production has been developed and
there is no missing part or aspect that
would need to be invented first [before
scaling up to industrial scale], "
says Wacker Chemie's Minge. The
main technical
challenge he sees
today is the following: " Unlike microbial
cells, mammalian cells take longer
to grow and are generally more prone
to impurities. They therefore need a
higher level of cleanness when being
grown. Maintaining a clean environment,
however, becomes more difficult
and more expensive, the larger
your overall production volumes are, "
he says. Minge believes the largest
vessels for mammalian cell cultures
in the pharma business today are in
the range of 20,000 L. " Some people
argue that volumes above 100,000 L
would be hard to achieve. I am more
optimistic here: on the one hand, it
has been shown that for another very
delicate type of cell (plant cells), production
on a 100,000-L scale is feasible;
on the other hand, I think that
there are also alternatives to scaling
up a batch process, for example scaling
out or continuous production. " n
Gerald Ondrey
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APRIL 2022
19

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Chemical Engineering April 2022

Table of Contents for the Digital Edition of Chemical Engineering April 2022

Chemical Engineering April 2022 - Cover1
Chemical Engineering April 2022 - Cover2
Chemical Engineering April 2022 - 1
Chemical Engineering April 2022 - 2
Chemical Engineering April 2022 - 3
Chemical Engineering April 2022 - 4
Chemical Engineering April 2022 - 5
Chemical Engineering April 2022 - 6
Chemical Engineering April 2022 - 7
Chemical Engineering April 2022 - 8
Chemical Engineering April 2022 - 9
Chemical Engineering April 2022 - 10
Chemical Engineering April 2022 - 11
Chemical Engineering April 2022 - 12
Chemical Engineering April 2022 - 13
Chemical Engineering April 2022 - 14
Chemical Engineering April 2022 - 15
Chemical Engineering April 2022 - 16
Chemical Engineering April 2022 - 17
Chemical Engineering April 2022 - 18
Chemical Engineering April 2022 - 19
Chemical Engineering April 2022 - 20
Chemical Engineering April 2022 - 21
Chemical Engineering April 2022 - 22
Chemical Engineering April 2022 - 23
Chemical Engineering April 2022 - 24
Chemical Engineering April 2022 - 25
Chemical Engineering April 2022 - 26
Chemical Engineering April 2022 - 27
Chemical Engineering April 2022 - 28
Chemical Engineering April 2022 - 29
Chemical Engineering April 2022 - 30
Chemical Engineering April 2022 - 31
Chemical Engineering April 2022 - 32
Chemical Engineering April 2022 - 33
Chemical Engineering April 2022 - 34
Chemical Engineering April 2022 - 35
Chemical Engineering April 2022 - 36
Chemical Engineering April 2022 - 37
Chemical Engineering April 2022 - 38
Chemical Engineering April 2022 - 39
Chemical Engineering April 2022 - 40
Chemical Engineering April 2022 - 41
Chemical Engineering April 2022 - 42
Chemical Engineering April 2022 - 43
Chemical Engineering April 2022 - 44
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Chemical Engineering April 2022 - 46
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Chemical Engineering April 2022 - 50
Chemical Engineering April 2022 - 51
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Chemical Engineering April 2022 - 53
Chemical Engineering April 2022 - 54
Chemical Engineering April 2022 - 55
Chemical Engineering April 2022 - 56
Chemical Engineering April 2022 - 57
Chemical Engineering April 2022 - 58
Chemical Engineering April 2022 - 59
Chemical Engineering April 2022 - 60
Chemical Engineering April 2022 - 61
Chemical Engineering April 2022 - 62
Chemical Engineering April 2022 - 63
Chemical Engineering April 2022 - 64
Chemical Engineering April 2022 - Cover3
Chemical Engineering April 2022 - Cover4
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