Chemical Engineering July 2022 - 4

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The 'Green' Chemistry Challenge
he Green Chemistry Challenge Awards recognize scientific
solutions to environmental problems that reduce hazards associated
with the design, manufacture and use of chemicals.
The U.S. Environmental Protection Agency (EPA) Office of
Chemical Safety and Pollution Prevention sponsors the awards in
partnership with the American Chemical Society (ACS) and other
members of the chemical community. This year, a new award category
for climate change was added to recognize technologies that
reduce or eliminate greenhouse gas emissions. A brief summary of
the 2022 winners follows [1]:
Greener Synthetic Pathways - Merck & Co., Inc. (www.merck.
com) has once again received this award for its achievement in creating
a " greener " process. Merck developed a process for manufacturing
molnupiravir (tradename LAGEVRIO), an antiviral medication for
treating COVID-19, with less organic solvent waste and less energy
use. Breakthroughs in the process development include a dynamic
crystallization with product selectively crystallizing as it is formed; direct
isolation by changing the solvents used, which decreased byproduct
formation and increased purity; and utilization of a novel
multi-enzyme cascade to increase the efficiency of the process.
Greener Reaction Conditions - Amgen (www.amgen.com) was
awarded this honor for an improved manufacturing process for sotorasib
(tradename LUMAKRAS), which is a drug for treating certain
non-small-cell lung cancers. Amgen decreased the number of reaction
steps in the commercial manufacturing process by using telescoped
synthesis. This involves creating sequential reactions in one vessel by
adding reagents one at a time, thereby eliminating intermediate separation
and purification steps. Additional changes, including a recycling
step, were also implemented to achieve a more sustainable process.
Small Business - Provivi (www.provivi.com) was recognized for its
green solution for crop protection against pests. Provivi's product,
tradenamed ProviviFAW, is a pheromone produced from renewable
plant oils. It targets the fall armyworm moth that is destructive to corn
and other crops. The company improved the reaction to make this
type of pheromone by using fermentation to produce raw materials
from plants instead of petroleum. In addition to creating a more sustainable
synthesis route, use of the pheromone in place of traditional
pesticides offers ecological benefits.
Academic - Professor Song Lin of Cornell University's Dept. of
Chemistry and Chemical Biology (www.cornell.edu) received this award
for developing a new route to manufacture complicated molecules that
are typically needed in pharmaceuticals. The technology employs an
electrochemical approach that uses inexpensive carbon or magnesium
electrodes and eliminates the need for transition metal catalysts.
Specific Environmental Benefit, Climate Change - Professor
Mark Mascal at the University of California at Davis (www.ucdavis.
edu) in partnership with Origin Materials (www.originmaterials.com)
was recognized for developing a process using acidic digestion of
biomass to make 5-(chloromethyl)furfural (CMF).
CMF is a bio-based platform chemical that can be
used to replace petroleum-based feedstocks to
manufacture a variety of chemicals. Origin Materials
has developed a process for polyethylene terephthalate
(PET) from CMF.
T
■
Dorothy Lozowski, Editorial Director
1. Source: EPA; more details about the winners and the awards can be
found on the EPA's website, www.epa.gov
CHEMICAL ENGINEERING WWW.CHEMENGONLINE.COM
JULY 2022
http://www.merck.com http://www.merck.com http://www.amgen.com http://www.provivi.com http://www.cornell.edu http://www.ucdavis,edu http://www.originmaterials.com http://www.ucdavis,edu http://www.accessintel.com http://www.epa.gov http://WWW.CHEMENGONLINE.COM
Chemical Engineering July 2022

Table of Contents for the Digital Edition of Chemical Engineering July 2022
