Chemical Engineering May 2021 - 9

AI-enabled design-and-test platform speeds
bioproduct development
eselaGen Biotechnology (San Francisco,
Calif.; www.teselagen.com) has
developed a platform technology that
integrates software and services, while
taking advantage of artificial intelligence (AI) by
applying machine-learning algorithms to reduce
the costs and time required for the development
of biologically derived products.
" Among the main challenges in biotechnolRO-3066I
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ogy is that developing bioproducts can take
years and cost millions of dollars, " says Eduardo
Abeliuk, CEO of TeselaGen. " We think of ourselves
as an operating system for biotech that
allows the end-to-end integration of different AIenabled
software modules with other product
development services. " As an analogy, Abeliuk
likens the way his company's platform works to
facilitate the interface with outside biotechnology
vendor systems and devices, to computer
software operating systems that allow desktop
computers to communicate with external computer
networks and device drivers.
The TeselaGen platform first helps research
and development scientists design combinatorial
libraries of desired molecules, such as DNA
and pathway assemblies - genes encoding enzymes
to carry out specific reactions, and DNA
sequences to regulate expression. The platform
then generates the instructions for laboratory
automation systems to synthesize and assemble
the segments for the project. Next, the DNA assemblies
are inserted into host cells to evaluate
the performance of different variations. The TeselaGen
system uses AI-trained models to guide
efficient experimentation that is aimed at identifying
the best-performing assemblies.
The TeselaGen platform grew out of a DNA
assembly protocol generator called " j5 " , initially
developed at the Joint Bioenergy Institute (Emeryville,
Calif.; www.jbei.org). The TeselaGen
platform has now been deployed in a variety of
settings, including the following: collecting data
for pilot-scale bioreactors at the Advanced Biofuels
and Bioproducts Process Development
Unit at Lawrence Berkeley National Laboratory
(Calif.; www.lbl.gov); developing new bioproducts
at LanzaTech Inc. (Skokie, Ill.; www.
lanzatech.com), and optimizing metabolic pathways
in yeast at the Technical University of Denmark
(Lyngby; www.dtu.dk).
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9

http://www.teselagen.com http://www.jbei.org http://www.lbl.gov http://www.lanzatech.com http://www.dtu.dk http://www.StaticMixers.com/Learn http://www.mixers.com/web-app http://adlinks.chemengonline.com/80069-06 http://WWW.CHEMENGONLINE.COM

Chemical Engineering May 2021

Table of Contents for the Digital Edition of Chemical Engineering May 2021