Chemical Engineering November 2020 - 27

tions, which describe process-induced material properties,
and numerical optimization tools, which allow fast
geometrical variations, Ultrasim builds the basis for designing
better parts, " emphasizes Andreas Wüst, team
leader for BASF Dynamic Structural Analysis, Europe.
The foundation for ensuring accurate materials simulation
is the underlying data. " The material-characterization
process generates the necessary data that are
essential in the accuracy in predicting real part behavior.
The theoretical material models developed for this purpose
are using the information from testing to calibrate
and therefore ensure the behavior represents real manufacturing
conditions and not an arbitrary case that is far
from reality, " Lambi points out. " There are complicated
assembly examples, such as automotive seating, which
are subjected to crash testing that utilize Ultrasim's predictive
accuracy to build parts that pass validation testing.
This dramatically reduces the development cycle
and minimizes, if not eliminates, design changes, " he
adds. Ultrasim also provides capabilities for the growing
market share of 3D-printed parts, which can now be
investigated using the tool, further accelerating the cycle
time from design to prototype to end product.
For the high-precision processes in research and development
and quality-analysis laboratories for biopharmaceutical
ingredients and other high-value products,
software tools can serve several purposes, including the
facilitation of an organization's business continuity plan
(BCP). " When looking at the laboratory, efficient software
can mitigate or reduce the number of risks, streamline
testing of events, have automated procedures to restore
the system once an event is over and even keep the
system running during an event, all simplifying the BCP, "
says Barbara van Cann, product marketing manager for
chromatography software in the Enterprise Chromeleon
Data System organization at Thermo Fisher Scientific
(Waltham, Mass.; www.thermofisher.com). Moreover,
laboratories can further streamline their BCP by selecting
integrated software that encompasses the chromatography
data system (CDS), the laboratory information-management
system (LIMS) and the laboratory
execution system (LES). " Both LIMS and CDS software
should provide tools to monitor instrument qualification,
calibration and maintenance, even down to individual
component parts, " explains Van Cann. The CDS software
should also help users to deal with analytics irregularities,
as well as have built-in network failure protection
to ensure continued operations, without manual interaction,
in the event of network outages. To avoid outages
due to cybersecurity attacks, Van Cann advises that
laboratories run CDS and other software on a domain
separated from main office systems to avoid potential
cyber-threats originating from emails. Finally, as with
any automated software platform, the human element
must be considered. " Human error can be reduced by
controlling what users can and cannot do, and can and
cannot access. In addition, there should be tools to automate
as many actions as possible. Less user interaction
equals fewer errors, " she adds.
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Chemical Engineering November 2020

Table of Contents for the Digital Edition of Chemical Engineering November 2020
