APR May/June 2023 - 77

« INTERPHEX AWARDS
Best New Product/Service - DEC Group
BoMa Dosing System. The BoMa technology has been designed to provide an effective solution
to work around speed, accuracy and flexibility problems encountered with current pumps. BoMa
technology operates with pressure and vacuum. The dosage of all components of a recipe can be
done in a few seconds, therefore providing high production capacities.
In the event of a product change, the installation is cleaned up very quickly due to the absence of
pumps. BoMa systems can be used in many situations, just like a piston pump. The main advantage
lies in the absence of seals, i.e. in the maintenance-free operation as well as in the ease of cleaning
when the product is changed.
Biotech Innovation - PAK BioSolutions Inc.
Pilot PAK System. Company developed a GMP modular continuous processing system that lowers
the hurdles of adopting new technologies. This technology was designed to (1) meet drug product
demand, (2) provide modular, mobile manufacturing, and (3) reduce environmental impact.
Demand for Covid mAbs increased 20X in 2.5 months. To meet such demand, the system increases
manufacturing capacity by employing continuous processing. The off-the-shelf system runs any
four unit operations simultaneously, resulting in 4X more product.
The modular design accommodates different products and processes. Single-use product-contact
surfaces allow for quick changes between products. The system is fully closed, can roll through a
standard door, and plug into a standard outlet, allowing deployment in various locations.
Environmental impact is minimized with compact, single-use equipment, eliminating the need for CIP and SIP systems. Combining four
steps shrinks facility footprint requirements another 60%.
Efficiency Champion - Thomas Processing
ACCELA CTC 500. Accela CTC is an advanced implementation of continuous tablet coating
technology. Whereas the benefits of continuous coating versus batch coating are already
understood, the Accela CTC coating system offers features never before implemented on
continuous coaters. With this equipment, the pharmaceutical industry can more readily embrace
continuous coating and realize its benefits in reduced consumption of raw materials, lower
demand for purified water, improved process efficiency, reduced waste and an overall faster
product lifecycle from development to pilot scale and onward to commercial production with
greater agility and fewer risks. Accela CTC is a continuous flow processing system that is used to
apply film coatings onto pharmaceutical tablets (compressed dosage forms). This equipment is
applied to satisfy demands that cannot otherwise be met in batch tablet coaters. These situations occur in scaleup and transfer for newly
developed drug products as well as cases where post-approval manufacturing changes are made to filed drugs already on market. Accela
CTC involves the process of continuously feeding tablets into one end of the perforated drum while a corresponding flow of coated
tablets is discharged at the other end. Pharmaceutical grade spray nozzles are used to atomize a coating solution and apply it to the bed
of continuously moving tablets. A combination of rotary " tumbling " motion is imparted along with the horizontal mass flow of incoming
material to create the desired mixing action and bed movement down the length of the drum. The coating is equally distributed across
the tablet bed. A continuous flow of heated air is delivered through the coater drum in a direction co-current with the coating spray. The
heated air evaporates the coating solution's solvent (typically water) to leave a thin, uniform film on the surface of the tablets. Accela
CTC solves several problems associated with batch processing, and it also solves problems found in earlier continuous coating systems.
www.americanpharmaceuticalreview.com |
| 77
»

http://www.americanpharmaceuticalreview.com

APR May/June 2023

Table of Contents for the Digital Edition of APR May/June 2023