» DRUG DEVELOPMENT » suggested based upon the data at hand. For example, alternative chromatographic conditions or inert systems can isolate the separation from the sample preparation. Communication of common liabilities also leads to more awareness of common risks, which allows us to identify opportunities to implement method development strategies to reduce the probability of risk. For example, a workflow change was implemented to reduce the second highest risk contributor in 2020, method selectivity, which was primarily identified in achiral LC methods. An improved LC column screening system was introduced over these two years, Figure 4. Year 2020 Metrics from Risk Surveys - Totaled from Medium and High Risk Figure 5. Year 2021 Metrics from Risk Surveys - Totaled from Medium and High Risk 24 | | November/December 2022