APR Sept/Oct 2023 - 103

SPONSORED CONTENT
Ejection Force with LUBRITAB® RBW vs. Stearic Acid
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50 100
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Tablet Hardness [N]
Fig. 1 Effect of Lubricant Choice and Level on the Ejection Force of
SMCC/Vitamin C Tablets.
Figure 1. Effect of Lubricant Choice and Level on the Ejection Force of SMCC/
Figure 1 shows a rank order performance of LUBRITAB®
RBW in ejection force values for Vitamin C formulation.
With respect to lubricant level, all but the lowest level
(0.25% LUBRITAB® RBW) produced acceptable ejection
forces. Surprisingly 2.0% stearic acid was needed to
produce an ejection force equivalent to that of only
0.5% LUBRITAB® RBW.
5
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50 100
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2.0%Stearic Acid
3.0%LUBRITAB® RBW
2.0%LUBRITAB® RBW
1.0%LUBRITAB® RBW
0.5%LUBRITAB® RBW
0.25% LUBRITAB® RBW
2.0%Stearic Acid
3.0%LUBRITAB® RBW
2.0%LUBRITAB® RBW
1.0%LUBRITAB® RBW
0.5%LUBRITAB® RBW
0.25% LUBRITAB® RBW
Figure 1. Effect of Lubricant Choice and Level on the Ejection Force of SMCC/
10
15
20
25
Tablet Hardness with LUBRITAB® RBW vs. Stearic Acid
Figure 2. Effect of Lubricant Choice and Level on the Tablet Hardness of SMCC/
Tablets
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500
5
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Compression Force [N]
Fig. 2 Effect of Lubricant Choice and Level on the Tablet Hardness of
SMCC/Vitamin C Tablets.
Figure 2. Effect of Lubricant Choice and Level on the Tablet Hardness of SMCC/
Tablets
Vitamin C
https://www.jrspharma.com/pharma_en/products/
promo/lubritab-rbw.php
Figure 2 shows a rank order performance of LUBRITAB®
RBW in tablet hardness values as well. As is common
with lubricants, an increase in lubricant level resulted
in a decrease in tablet hardness. This reduction in
hardness was across a wide range of lubricant level
(from 0.25 - 3.0%) and tablets of satisfactory (200 N)
hardness were still achievable.
Disclaimer
The information provided in this brochure is based on thorough
research and is believed to be completely reliable. Application suggestions
are given to assist our customers, but are for guidance only.
Circumstances in which our material is used vary and are beyond our
control. Therefore, we cannot assume any responsibility for risks or
liabilities, which may result from the use of this technical advice.
Key Words: Vitamin C, Direct Compression, Health
Supplement
JRS Products: LUBRITAB® RBW, PROSOLV® SMCC 90,
VIVASOL® CCS
25
30
Find out more about LUBRITAB® RBW on
2.0% Stearic Acid
3.0% LUBRITAB® RBW
2.0% LUBRITAB® RBW
1.0% LUBRITAB® RBW
0.5% LUBRITAB® RBW
0.25% LUBRITAB® RBW
Vitamin C
Vitamin CTablets
350
400
450
2.0% Stearic Acid
3.0% LUBRITAB® RBW
2.0% LUBRITAB® RBW
1.0% LUBRITAB® RBW
0.5% LUBRITAB® RBW
0.25% LUBRITAB® RBW
Tablets formulated with 0.5% LUBRITAB® RBW were
almost as hard as those formulated with stearic acid at
2.0%.
It should be noted that while LUBRITAB® RBW has
been observed in some cases to act like a binder
(actually increasing tablet hardness as the input level is
increased), this appears to be dependent on the choice
of both API and binder.
With Vitamin C and PROSOLV® SMCC 90 there was
some picking observed on the tablets made with 2-3%
LUBRITAB® RBW, particularly at the lowest compaction
levels. This suggests that when there are formulations
containing very sticky actives, the additive effect of the
adhesive characteristics of LUBRITAB® RBW may need
to be moderated with the addition of an anti-adherent.
Conclusion
Vitamin CTablets
30
LUBRITAB® RBW was found to be well-suited for the
production of Vitamin C tablets by direct compression.
The tablets showed sufficiently low ejection forces
at lubricant levels equal to or greater than 0.5%
LUBRITAB® RBW, and reasonable tablet hardness at all
lubricant levels.
In the case of Vitamin C, the recommended level of
LUBRITAB® RBW to optimize both tablet hardness and
ejection forces is 0.5-1.0%.
U.S. HEADQUARTERS
JRS PHARMA LP
2981 Route 22, Patterson, NY 12563
Phone: (845) 878-3414
info@jrspharma.com
www.jrspharma.com
Tablet Hardness [N]
Ejection Force [N]
04_28_2023v7
https://www.jrspharma.com/pharma_en/products/ http://www.jrspharma.com
APR Sept/Oct 2023

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