APR Sept/Oct 2023 - 119

« SECTION TITLE
Antimicrobial Guanidinium
and Thiouronium
Functionalized Polymers;
W. Chin, J. L. Hedrick, N. L. Ibrahim,
A.L.Z. Lee, R. J. Ono, Q. Xu and Y.Y.
Yang; International Business Machines
Corp. , USA and Agency for Science,
Technology and Research, Singapore;
U.S. Patent # 11,690,380; July 4, 2023.
Currently, microbes developing drug resistance is a serious
problem. Effective and unconventional antimicrobial
agents have been developed in recent times. In this patent,
cationic antimicrobial agents using polycarbonate and
polyurethane polymer backbones were prepared, which
included guanidium and thiouranium functionalities. These
are broad spectrum agents effective against gram-positive,
gram-negative bacteria and/or fungus. These agents are
biodegradable and have low cytotoxicity.
Compositions with Sulfur Having
Enhanced Efficacy and Aesthetics;
E.S. Johnson, B.S. Lane, S. N. Jamadagni,
A.J. Yeary, and M. Caggioni; The Procter
& Gamble Company, USA; U.S. Patent #
11,679,065; June 20, 2023.
The present invention is directed to personal care compositions
where it has been surprisingly found that the addition of larger
particles of sulfur provides strong efficacy while minimizing
inherent sulfur malodor aesthetics. Conventional wisdom in
the anti-dandruff shampoo category has found that achieving
the maximum efficacy benefit from deposited particulate
antidandruff (AD) actives is a function of reducing particle size
and maximizing deposition on the scalp. On the contrary, it has
found that the opposite applies when working with sulfur. The
present invention has shown that due to sulfur's higher solubility
in sebum, reducing its surface area on scalp via increasing the
particle size ensures a significantly longer residence time of
the active on the scalp. The malodors are formed when sulfur
interacts with specific chemical moieties in the skin to produce
strong smelling compounds. By minimizing the amount of sulfur
that is deposited on skin while maintaining efficacious dosing via
use of sulfur with an increased particle size, the expected tradeoff
between clinical performance and cosmetic acceptance can be
significantly mitigated.
Regulation of Cancer Using
Natural Compounds and/or Diet;
B.A. Reynolds and L.P. Deleyrolle;
University of Florida Research
Foundation, Inc.; USA; U.S. Patent #
11,666,549; June 6, 2023.
O.H. Warburg found that cancer cells tend to use
fermentation for obtaining energy even in aerobic
conditions. Cancer cells take up high levels of glucose
followed by glycolysis. Cancer treatment uses highly
effective, but toxic drugs. The patent proposes a use of
non-toxic compounds affecting the inefficient energy
consumption by cancer cells. The inventors propose to
use 1. Epigallocatechin-3 gallate, 2. Curcumin and 3.
Glucoraphanin and/or sulforaphane along with a ketogenic
diet in addition to a typical anticancer treatment. Dikon
radish sprout or its extract might also be used.
Chemical Ablation Formulations
and Methods of Treatments for
Various Diseases;
L. Wang; Neurotronic, Inc., USA; U.S.
Patent # 11,684,417; June 27, 2023.
Chemical ablation is a technique in which the chemical ablative
substances are used to cause cell death in neoplastic tissue. The
cell damage takes the form of cell membrane damage, protein
denaturation, and cellular dehydration. The method involves
delivering formulation and thermal energy to the target diseased
tissue. The method includes inserting a needle-based balloon
delivery catheter, inflating the balloon, infusing a chemical
formulation at a suitable temperature and pressure, deflating the
balloon and withdrawing the catheter.
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