Pharmaceutical Outsourcing Q3 2023 - 25

CLINICAL TRIALS
SECTION TITLE
being used to continuously monitor patients' biochemical, physiological,
and movement endpoints outside the clinic. Data from these devices
can help inform and monitor treatment choices, as well as influence
preventative care measures. Collective data from wearables can also
be used in the development of predictive algorithms that help guide
more personalized treatment. Application is possible in many areas
of healthcare, including metabolic, cardiovascular, gastrointestinal,
neurologic, pulmonary and mental health; sleep and movement
disorders; maternal and pre- and neonatal care; and monitoring of
environmental exposures.8
Rare Diseases
While precision medicine first gained ground in oncology, where
genetic knowledge about specific cancers is helping to target
treatments, its use is rapidly expanding to other treatment areas-
including notoriously
difficult-to-treat
rare diseases-thanks to
better access to and application of big data, as well as increased
accessibility of advanced technologies like genetic sequencing,
artificial intelligence, and spatial genomics.9
" TuPro " Multi-omics
Tumor Profiler
While genetic characterization of tumors has become increasingly
common in cancer diagnosis and treatment, the TuPro integrated
treatment-recommendation protocol developed by a Swiss research
consortium moves a step farther. As shown in Figure 1, TuPro analyzes
multiple additional " omics " data points, including a tumor's highresolution
molecular profile and its ex vivo drug response-all within
clinically relevant turnaround times. It is a great example of leveraging
multiple data types to inform personalized treatment decisions.10
Figure 1. The TuPro approach leverages multiple advanced technologies to attain a more complete picture of patient tumors
and their microenvironments, which helps deliver clinically relevant insights in short turnaround times. (Anja Irmisch, Ximena
Bonilla, Stéphane Chevrier, et. al.Cancer Cell. 39(3) [2021]).
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Pharmaceutical Outsourcing Q3 2023

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