Pharmaceutical Outsourcing Q3 2023 - 8

CNPerspectives
Pharmaceutical Outsourcing is one of several outstanding publications available from CompareNetworks, Inc.
Here is a look at the insightful content our readers may enjoy from four of our sister resources: American Pharmaceutical Review,
Biocompare, Labcompare, and Tablets & Capsules.
Managing A Cleanroom Cleaning Team
We often take for granted the human aspect of meeting objectives for compliance. While the patient is
our ultimate customer, developing a program of contamination control is complex and is significantly
dependent on proper human behavior to achieve successful outcomes. The interdependencies of a robust process, quality of input
materials, controlled facility and equipment, and operators following validated procedures are the parts of a puzzle that must fit well to
ensure successful implementation of a contamination control strategy.
https://bit.ly/449WK9g
IVT mRNA in Regenerative Medicine
Although messenger RNA (mRNA) was discovered in 1961, it took nearly 30 years for its therapeutic
potential to come to light. In 1990 a group at the University of Wisconsin injected RNA expression vectors for the proteins chloramphenicol
acetyltransferase, luciferase, and beta-galactosidase into mouse skeletal muscle and detected protein expression " in all cases " with " no
special delivery system ... required for these effects. " Moreover, expression levels were comparable to those obtained through transfected
fibroblast DNA delivery, which the Wisconsin researchers ran as the control. Researchers reported that protein production was confined to
muscle and persisted for at least two months.
https://bit.ly/3OSdtK1
Rapid and Cost-Effective NGS Workflows through Automated
Liquid Handling
Next-generation sequencing (NGS) has changed the face of research, giving scientists deeper insights into the most challenging
problems. As the cost of sequencing continues to decrease, NGS technology is becoming more accessible, subsequently appearing
in diverse research applications from disease-specific panel development to the creation of personalized medicines. However, the
broader utility and accessibility of NGS comes with a corresponding growth in the number of samples that labs are required to handle.
https://bit.ly/3qsQlZ6
Encouraging Integration: Fostering Relationships Between
Formulators, Specialty Chemical Producers, and Excipient
Suppliers Creates a Stronger Supply Chain
Pick up the annual report of any generic pharma company like Teva, Sandoz, Aurobindo Pharma, etc. and it will likely include claims
about being an integrated pharma company. But really, what does " integration " mean, to what extent do they do so, and how do they
accomplish it? First, the definition: for our purposes, integration means communication between suppliers of specialty chemicals,
active pharmaceutical ingredients (APIs), and excipients. The " why " involves equalizing asymmetric relationships between suppliers and
formulators-because these create issues in the supply chain.
https://bit.ly/3sahdh6
Pharmaceutical Outsourcing | 8 | July/August/September 2023

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Pharmaceutical Outsourcing Q3 2023

Table of Contents for the Digital Edition of Pharmaceutical Outsourcing Q3 2023