eBook: Formulation of Dry Powder Inhaler - 36
Simultaneous Spray Drying for
Innovative Dry Powder Inhaler
Combination Formulations
Recent developments in spray drying have facilitated
new and previously impractical formulation
strategies. Combination therapies delivered directly
to the lung by dry powder inhalants are an effective
means of reducing patient burden and improving
care. Despite this, their use has been historically limited
by the compatibility of the active pharmaceutical
ingredients (APIs) combinable through micronization
and blending.
Simultaneous spray drying, a process by which two
distinct APIs are simultaneously atomized through
separate nozzles into a single spray dryer, is useful
for a range of applications, from small molecules to
biological actives and proteins. Employing simultaneous
spray drying for biologics and advanced
therapies will represent a crucial shift for treatment
- currently, limited options exist for preparing combination
treatments that contain both small molecule
APIs and biotherapeutic molecules.
Lonza, a global contract development and manufacturing
organization (CDMO), possesses a wealth of
expertise in respiratory drug formulation and manufacturing;
its respiratory delivery center of excellence
in Bend, OR, has performed particle engineering
for pharmaceutical applications for more than
three decades. This work has culminated in a number
of successes, including recent advancements
in simultaneous spray drying for combination dry
powder formulations to treat lung cancer.
In a recent webinar, " Simultaneous Spray Drying
for Innovative Dry Powder Inhaler Combination
Formulations, " Dr. Kimberly Shepard, principal research
and development engineer for Lonza, explored
Lonza's successes with its
process, including case studies illustrating the potential
for these drugs in improving care for critically
ill patients.
The Challenges and Opportunities for
Combination Inhaled Therapies
Designing and formulating drugs for inhalation can
be challenging in many respects. These difficulties
begin with the nature of treating the lungs with inhalation
formulations - because the lungs, by design,
work to filter out foreign particulates. Ensuring
adequate delivery of a drug product requires a particular
focus on the particle diameter and density of
a therapeutic. These variables in combination are
referred to as a particle's " aerodynamic diameter, "
which determines whether it is capable of reaching
the portions of the lung necessary to facilitate effective
treatment. Particles with too large of an aerodynamic
diameter - typically more than five microns
- become trapped in the upper airway; conversely,
" simul-spray "
36
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eBook: Formulation of Dry Powder Inhaler
Table of Contents for the Digital Edition of eBook: Formulation of Dry Powder Inhaler
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