a higher level of humanistic features as well as complex cell signaling that could potentially play a role in better understanding the effects of innovative therapies. The purpose of this information is to further elucidate and characterize organoids in the context of a disease model by providing a more in-depth analysis of the composition of organoids and its innate biological functions in different organ contexts such as the brain and heart. In conclusion, organoids are poised to play a significant role in the development of the next generation of therapies and alleviate the challenges in translating therapies from discovery to the clinic. References 1. Liguore, W. A. et al. AAV-PHP.B Administration Results in a Differential Pattern of CNS Biodistribution in Nonhuman Primates Compared with Mice. Mol. Ther. 27, 2018-2037 (2019). 2. Pas, S. P. The rise of three-dimensional human brain cultures. Nat. 2018 5537689 553, 437-445 (2018). 3. Depla, J. A. et al. Cerebral Organoids: A Human Model for AAV Capsid Selection and Therapeutic Transgene Efficacy in the Brain. Mol. Ther. - Methods Clin. Dev. 18, 167-175 (2020). Additional Resource Aneuro Advance Neuroscience Research 18https://www.acrobiosystems.com/A2369-Aneuro.html?utm_source=biocompare&utm_medium=blog&utm_campaign=1656Ao23&utm_content=CYGGEN6397&utm_term=Neuroscience