Contents 3 6 Neuroscience Complexity Clarified by Organoids and Advanced Imaging Metabolic assays, in 3D assemblies and other cell cultures, are providing valuable biomedical insights Neuroinflammation's Role in Neurodegenerative Disease An in-depth exploration of the key components and mechanisms involved in neuroinflammation is critical for the treatment of neurodegenerative diseases 13 Characterization of Organoids as a Preclinical Disease Model for Neuroscience Organoids are poised to alleviate the challenges in translating therapies from discovery to the clinic 19 Fluorescence-based Calcium Mobilization Assay with the CELENA® X High Content Imaging System An optimized analysis pipeline to evaluate ATP-induced intracellular calcium flux Produced with Support from Biocompare 395 Oyster Point Blvd., Suite 300 South San Francisco, CA 94080 Tel: 800-637-1277 info@biocompare.com www.biocompare.com 2http://www.biocompare.com