eBook: Advanced Tools Transforming Neurology Research - 6

Neuroinflammation's Role in
Neurodegenerative Disease
An in-depth exploration of the key components and mechanisms
involved in neuroinflammation is critical for the treatment of
neurodegenerative diseases
Neuroinflammation is a complex process that involves
both the central nervous system (CNS) and
the peripheral circulation, which is considered to
be associated with many neurological disorders,
including Alzheimer's disease (AD), Parkinson's
disease (PD), and depression (Figure 1). This inflammation
usually involves the activation of glial
cells, the release of inflammatory mediators such
as cytokines and chemokines, and the production
of reactive oxygen species and secondary messengers.1-5
Pro-inflammatory
cytokines like tumor necrosis
factor-alpha (TNF-a) and interleukin-1 beta
(IL-1B), the NF-kB and MAPK cell signaling pathways,
and the neuroinflammatory regulator TREM2
are some of the factors involved in orchestrating
immune responses within the CNS.6-9
Additionally,
microglia and macrophage markers, toll-like receptors
(TLRs), and anti-inflammatory cytokines such
as IL-10 and TGF-β are key players in the neuroinflammatory
landscape.10,11
Emerging trends
Biomarkers like GFAP
and MBP further aid in diagnosing and monitoring
neuroinflammatory diseases.12
in neuroinflammation research include the use of
brain organoids, cultivated from pluripotent stem
Figure 1. Schematic depiction of shared molecular signaling cascade
among protein aggregates associated with Alzheimer's disease,
tauopathies, and Parkinson's disease. This cascade is initiated
by the activation of microglia in response to signals of cellular
damage. https://doi.org/10.3389/fphar.2019.01008
6

https://www.sinobiological.com/areas/neuroscience/neurodegenerative-disease?utm_source=biocompare&utm_medium=ebook&utm_campaign=dec-neurology https://www.sinobiological.com/category/tnf-alpha?utm_source=biocompare&utm_medium=ebook&utm_campaign=dec-neurology https://www.sinobiological.com/category/il-1-beta?utm_source=biocompare&utm_medium=ebook&utm_campaign=dec-neurology https://www.sinobiological.com/category/nf-kb-p65?utm_source=biocompare&utm_medium=ebook&utm_campaign=dec-neurology https://www.sinobiological.com/category/trem-2?utm_source=biocompare&utm_medium=ebook&utm_campaign=dec-neurology https://www.sinobiological.com/category/trem-2?utm_source=biocompare&utm_medium=ebook&utm_campaign=dec-neurology https://www.sinobiological.com/category/tlr3?utm_source=biocompare&utm_medium=ebook&utm_campaign=dec-neurology https://www.sinobiological.com/category/il-10?utm_source=biocompare&utm_medium=ebook&utm_campaign=dec-neurology https://www.sinobiological.com/category/tgf-beta-1?utm_source=biocompare&utm_medium=ebook&utm_campaign=dec-neurology https://www.sinobiological.com/category/gfap?utm_source=biocompare&utm_medium=ebook&utm_campaign=dec-neurology https://doi.org/10.3389/fphar.2019.01008 https://www.sinobiological.com/category/ads/brain-organoid-cytokines?utm_source=biocompare&utm_medium=ebook&utm_campaign=dec-neurology

eBook: Advanced Tools Transforming Neurology Research

Table of Contents for the Digital Edition of eBook: Advanced Tools Transforming Neurology Research

eBook: Advanced Tools Transforming Neurology Research - 1
eBook: Advanced Tools Transforming Neurology Research - 2
eBook: Advanced Tools Transforming Neurology Research - 3
eBook: Advanced Tools Transforming Neurology Research - 4
eBook: Advanced Tools Transforming Neurology Research - 5
eBook: Advanced Tools Transforming Neurology Research - 6
eBook: Advanced Tools Transforming Neurology Research - 7
eBook: Advanced Tools Transforming Neurology Research - 8
eBook: Advanced Tools Transforming Neurology Research - 9
eBook: Advanced Tools Transforming Neurology Research - 10
eBook: Advanced Tools Transforming Neurology Research - 11
eBook: Advanced Tools Transforming Neurology Research - 12
eBook: Advanced Tools Transforming Neurology Research - 13
eBook: Advanced Tools Transforming Neurology Research - 14
eBook: Advanced Tools Transforming Neurology Research - 15
eBook: Advanced Tools Transforming Neurology Research - 16
eBook: Advanced Tools Transforming Neurology Research - 17
eBook: Advanced Tools Transforming Neurology Research - 18
eBook: Advanced Tools Transforming Neurology Research - 19
eBook: Advanced Tools Transforming Neurology Research - 20
eBook: Advanced Tools Transforming Neurology Research - 21
eBook: Advanced Tools Transforming Neurology Research - 22
eBook: Advanced Tools Transforming Neurology Research - 23
https://www.nxtbookmedia.com