eBook: Breakthroughs and Innovations in Immunology Research - 6

development to address safety concerns and expand
their applicability.
Other CAR therapies are less well known but are
also promising therapeutics. CAR NK (natural kill)
cells,5
immunotherapies a reality for more patients who
desperately need them. Access our entire eBook to
learn more about the latest advances in immunology
research tools and therapeutics.
for example, have been in use for two decades
to treat advanced-stage leukemia. CAR NK
cells are particularly attractive because they have
several safety advantages over CAR T cells, which
can induce severe, life-threatening immune reactions.
CAR M (macrophage)6
cells are also in development
as an addition to the CAR cell toolbox.
In Chapter 4 of this eBook, we take a deep dive into
CAR therapies, outlining the pros and cons of each
and undergoing efforts to improve and optimize
CAR T, CAR NK and CAR M therapies and how Sino
Therapeutics is supporting those efforts through
their world-class reagents and services.
Concluding remarks
Immunotherapies are a promising approach for
treating a variety of diseases. Basic tools supporting
immunology research are essential for our
understanding of the immune system and the
development of novel immunotherapies, and several
advances in these tools have significantly expanded
our research capabilities. By continuing to
invest in new tools and technologies, we can make
References
1. Abbas AK, Lichtman AHH, and Pillai S. Cellular and
Molecular Immunology. 9th Ed. Elsevier; 2018.
2. Arnaoutova I, George J, Kleinman HK, and Benton G.
Basement Membrane Matrix (BME) has Multiple Uses
with Stem Cells. Stem Cell Rev Reports. 2012;8:163-169.
3. Lopera Higuita M., Shortreed NA, Dasari S, and
Griffiths LG. Basement Membrane of Tissue
Engineered Extracellular Matrix Scaffolds Modulates
Rapid Human Endothelial Cell Recellularization
and Promote Quiescent Behavior After Monolayer
Formation. Front Bioeng Biotechnol. 2022;10:1-15.
4. Maakaron JE and El Jurdi N. Chimeric antigen receptor
T cell therapy for cancer: clinical applications and
practical considerations. BMJ. 2022; 378.
5. Xhang L, Meng Y, Feng X, and Han Z. CAR-NK cells
for cancer immunotherapy: from bench to bedside.
Biomarker Res. 2022;10(1):12.
6. Wang S, Yang Y, Ma P, Zha Y, Zhang J, Anhua L et al.
CAR-macrophage: An extensive immune enhancer to
fight cancer. eBiom. 2022;76:103873.
6
eBook: Breakthroughs and Innovations in Immunology Research

Table of Contents for the Digital Edition of eBook: Breakthroughs and Innovations in Immunology Research
