eBook: New Frontiers in Infectious Disease Research - 23

identification and monitoring of bacteria, fungi,
viruses, and parasites in both research and clinical
settings. Through novel host depletion, insight
from mNGS can fully transform our relationship
with microorganisms to benefit our health and
sustainability. To learn more or sample a kit, visit
www.micronbrane.com/bc23.
References
1. Chiu CY, Miller SA. Clinical metagenomics. Nat Rev
Genet. Jun 2019;20(6):341‐355. doi: 10.1038/s41576019-0113-7
2.
Charalampous T, et al. Rapid Diagnosis of Lower
Respiratory Infection using Nanopore-based
Clinical Metagenomics. bioRxiv. 2018:387548.
doi:10.1101/387548
3. Hasan MR, et al. Depletion of Human DNA in Spiked
Clinical Specimens for Improvement of Sensitivity of
Pathogen Detection by NextGeneration Sequencing.
Journal of Clinical Microbiology. 2016;54(4):919-927.
doi:doi:10.1128/JCM.03050-15
4. Marotz CA, et.al. Improving saliva shotgun
metagenomics by chemical host DNA depletion.
Microbiome. 2018/02/27 2018;6(1):42. doi:10.1186/
s40168-018-0426-3
5. Nelson MT, et al. Human and Extracellular DNA
Depletion for Metagenomic Analysis of Complex
Clinical Infection Samples Yields Optimized Viable
Microbiome Profiles. Cell Reports. 2019;26(8):22272240.e5.
doi:10.1016/j.celrep.2019.01.091
6. Feehery GR, et al. A method for selectively enriching
microbial DNA from contaminating vertebrate
host DNA. PLoS One. 2013;8(10):e76096- e76096.
doi:10.1371/journal.pone.0076096
7. Oyola SO, et al. Efficient Depletion of Host DNA
Contamination in Malaria Clinical Sequencing.
Journal of Clinical Microbiology. 2013;51(3):745-751.
doi:doi:10.1128/JCM.02507-12
8. Feehery GR, et al. A method for selectively enriching
microbial DNA from contaminating vertebrate
host DNA. PLoS One. 2013;8(10):e76096- e76096.
doi:10.1371/journal.pone.0076096
9. Data on file.
10. Chen YC, et.al. Evaluation of a Metagenomic NextGeneration
Sequencing Assay with a Novel Host
Depletion Method for Pathogen Identification in
Septic Patients. medRxiv 2023.03.28.23287867; doi:
https://doi.org/10.1101/2023.03.28.23287867
Additional Resource
PaRTI-Seq™ Workflow for Samples of
Small Volume
23

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eBook: New Frontiers in Infectious Disease Research

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