eBook: Optimizing Cell Culture Techniques - 18

Semi-Automated Medium
Exchange in InSphero Akura 96
and 384 Spheroid Microplates with
the VIAFLO 96 and VIAFLO 384
Handheld Electronic Pipettes
Efficient and precise liquid handling protocol with the VIAFLO 96
and VIAFLO 384 handheld electronic pipettes
3D human in vitro cell models are gaining increased
importance in the drug discovery and development
cycle of the pharmaceutical industry as they mimic
the human in vitro responses of newly developed
substances more precisely than 2D models. They
can help to bridge the gap between the traditional
2D in vitro models and whole-animal systems as the
traditional models do not effectively recapitulate
the more complex signaling and cellular interactions
found in vivo. Spheroids are scaffold-free 3D
cell culture models that are aggregated from one or
more organ-specific cell types.
InSphero has developed 3D cell-based assay solutions
in the fields of liver toxicology, metabolic
diseases, and oncology. Industrial use of these
complex in vitro systems requires a perfect match
of the tissue model, cell culture plates and liquid
handling instrumentation. InSphero's Akura 96
and 384 Spheroid Microplates have been engineered
for the generation, long-term cultivation,
observation and testing of spheroids in 96 and
384 well formats in a simple, flexible, and automation-compatible
platform. Its scalable format
requires liquid handling systems for convenient,
yet quick, reliable, and precise medium exchange,
sampling, dosing, and spheroid transfer from multiple
plates. The semi-automated VIAFLO 96 and
VIAFLO 384 handheld electronic pipettes are ideal
for these routine lab tasks, offering 96 and 384
channel pipetting in a compact and easy-to-use
platform, for increased productivity.
Key benefits
* The ultra-low attachment Akura 96 and
384 Spheroid Microplates allow convenient
scaffold-free formation of spheroids-one per
well-below 750 μm via cellular self-assembly.
18
eBook: Optimizing Cell Culture Techniques

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