MJBizMag July 2022 - 42

Research Renaissance
CLINICAL STUDIES
Universities and research institutes evaluate effectiveness of CBD
and THC against various ailments
T
he following tables contain
observational and interventional
clinical studies* involving
marijuana-derived CBD and THC.
These are but a thimbleful of the
cannabis studies undertaken in
recent decades.
Federally funded research into
cannabis has had an overwhelmingly
negative bias, focusing on issues such
as addiction, how the plant affects the
teenage brain and how to measure
and detect impairment. Such anticannabis
research continues today,
only moderately tempered.
What has changed is that there
are significantly more therapeutic
studies, such as those exploring
whether cannabis relieves pain, helps
Alzheimer's patients with cognition or
reduces tremors related to Parkinson's
disease.
While most of these studies involve
CBD, a significant number involve THC.
What follows is only a sampling and is
not meant to present the full range of
cannabis research taking place.
* In an observational cannabis study, participants consume an " intervention " -say, cannabis flower or edibles-and are assessed for
biomedical or health outcomes. These studies do not lead to new drug approvals. In interventional studies, researchers assign interventions
such as drugs or behavioral counseling to participants and evaluate the health outcomes and/or their efficacy in combatting symptoms or
illness compared to existing treatments and placebos. These studies might lead to new drug approvals.
Ongoing Interventional Studies
Reducing Pain and
Opioid Use With CBD
Conditions
Interventions
Sponsor/
collaborators
Enrollment
Funded by
Completion date
Opioid-use disorder
CBD
University of Colorado
at Denver
150
Other
February 2027
Brief summary
Assess the tolerability
and efficacy of fsCBD and
bsCBD to reduce opioid
use, anxiety and pain
and improve sleep and
cognitive function.
Cannabidiol for
Reduction of Brain
Neuroinflammation
Back pain, depressive
symptoms
CBD
Massachusetts
General Hospital
80
Other
Dec. 15, 2026
Investigate if CBD exerts
anti-neuroinflammatory
effects in patients with
chronic low back pain,
with or without mild to
moderate depression.
Therapeutic Response
of Cannabidiol in
Rheumatoid Arthritis
Rheumatoid arthritis
CBD
UCLA
60
Other
June 10, 2025
Safety and Effects on
Responses to Stress
and Pain of Natural
Medical Marijuana
Products
Pain
CBD and THC
Yale University, Connecticut
Pharmaceutical Solutions
36
Other
Dec. 1, 2023
Examine the efficacy of CBD
treatment for rheumatoid
arthritis.
Examine the safety
and pharmacokinetic/
pharmacodynamic profile
and the physiologic,
neuroendocrine and
behavioral stress and pain
responses to acute single
doses and repeated dosing
of oral CBD alone and in
combination with THC and
matched placebo.
42 Julu 2022 | MJBizMagazine

MJBizMag July 2022

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