April 2023 - 21

dr. bugs
BY RAYMOND A. CLOYD
Anthranilic Diamide Insecticides
Question: Can you please provide information on the insecticides
associated with the Insecticide Resistance Action Committee
(IRAC) group 28?
Answer: Insecticides
in the IRAC group 28 are
referred to as anthranilic
diamides. There are
three IRAC group 28
insecticides labeled
for use in greenhouse
production systems:
Acelepryn, Mainspring
and Sarisa. Acelepyrn
(with active ingredient
of chlorantraniliprole)
is labeled for use
against caterpillars
Raymond A.
Cloyd is professor
and Extension
specialist in
horticultural
entomology/
plant protection
at Kansas State
University. He
can be reached at
rcloyd@ksu.edu.
(foliar application) and aphids
(growing medium application).
Mainspring (with active
ingredient of cyantraniliprole)
is labeled for use against
aphids, thrips and whiteflies
(foliar and growing medium
applications). Sarisa (with active
ingredient of cyclaniliprole)
is labeled for use against
caterpillars, beetles, leafminers,
mealybugs, thrips and
whiteflies (foliar application).
There is another insecticide
product, Pradia, which is
a mixture of cyclaniliprole
(the active ingredient in
Sarisa) and flonicamid (the
active ingredient in Aria).
Anthranilic diamide
insecticides are mobile in the
xylem (water-conducting tissues)
but have a low water solubility
ranging from 0.10 to 14.2 ppm
(mg/L). Anthranilic diamide
COMMON NAME
TRADE
NAME
REI
TARGETED
INSECT
PESTS
Chlorantraniliprole Acelepryn 4 hours
Caterpillars
and aphids
Cyantraniliprole
Cyclaniliprole
Mainspring 4 hours
Sarisa
4 hours
Aphids,
thrips and
whiteflies
Caterpillars,
thrips and
whiteflies
WATER
SOLUBILITY
(AT PH=7)
0.88 ppm
(mg/L)
14.2 ppm
(mg/L)
0.10 ppm
(mg/L)
Table 1. Common name (active ingredient), trade name, restricted
entry interval (REI), targeted insect pests (based on label information)
and water solubility of Insecticide Resistance Action Committee (IRAC)
group 28 insecticides.
insecticides have contact,
translaminar or systemic
activity against targeted insect
pests. Studies have indicated
that anthranilic diamide
insecticides may have repellent
or antifeedant properties.
The mode of action of
anthranilic diamide insecticides
is associated with modulation
or varying the properties of the
ryanodine receptors (ryanodine
receptor modulators). Normally,
ryanodine receptor channels
regulate the movement of
calcium within muscle cells of
the insect, which is important
for muscle contraction and
relaxation. Anthranilic diamide
insecticides bind to the
ryanodine receptors, which
keeps the channels open,
resulting in an uncontrolled
release of stored muscle calcium
from cells. Consequently, normal
muscle contraction is disrupted
leading to paralysis and
eventually death of insect pests.
Studies have shown
anthranilic diamide insecticides
are not harmful to bees and
certain biological control
agents. In our research at
Kansas State University in
Manhattan, Kansas, however,
we found that cyantraniliprole
(Mainspring) was directly
harmful to adults of the rove
beetle, Dalotia coriaria, and
insidious flower bug, Orius
insidiosus. Table 1 presents
information associated
with the IRAC group 28
insecticides.
GREENHOUSE PRODUCT NEWS 21
April 2023

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