Fall 2023 - 29

forming, acting as an antioxidant to reduce
oxidative stress following a mTBI. As a result,
supplementation with creatine may decrease
an individual's vulnerability for Second Impact
Syndrome, which is associated with the altered
metabolic environment following a concussion.
SUMMARY
Following a concussion, omega-3 fatty acids,
and magnesium are common supplements
provided and/or recommended that may help
with post-concussion symptoms. Because of
the large role creatine plays in resynthesizing
ATP in the brain, the addition of creatine
supplementation to a post-concussion protocol
may also be an emerging intervention. Due
to the energy crisis following a concussion,
creatine may help the brain meet these higher
energy demands by increasing the rate at which
ATP resynthesizes. Creatine supplementation
may also reduce the side effects associated
with the altered metabolic environment in
the brain following a concussion, including
increased intracellular calcium, apoptosis, and
oxidative stress.
While these potential mechanisms seem to
be promising, there are currently zero clinical
research studies done in athletes testing
whether supplementation directly improves
outcomes following a concussion. However, it
is still important for medical professionals in
the sports environment to consider the benefits
that creatine supplementation can have when
dealing with concussions, and to stay alert for
how future randomized controlled trials guide its
potential use. n
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Fall 2023

Table of Contents for the Digital Edition of Fall 2023
