October/November 2020 - 33

Therapy
pilot study. Then we did a large prospective randomized
trial of 230 patients (at) 12 centers across the United
States. We gathered elite data showing that PRP worked
for tennis elbow.
I've also done some basic science studies that have
shown that PRP can help stem cells proliferate. I also
have some other data that shows that PRP helps if I
injected your patellar tendonitis or your elbow. PRP acts
as what's called a chemoattractant, or it sort of pulls at
your stem cells. Because I actually didn't understand
completely how a single injection of PRP would make
such a big difference.
Right now in the United States using stem cells, or
providing different versions is very challenging because
(of) the regulations; it's not necessarily used that often.
(The use of stem cells is) most often just in clinical trials,
but PRP is widely used. Unstaggered. Flat out staggered
how much PRP is used across the country and the world.
TC: You brought up how early on when you first looked
into PRP, people were asking questions about it. I know
with stem cells, when I see " stem cell " attached to
anything, there's always this apprehension. Do you still
hear questions when it comes to that? And what's the
difference between PRP and stem cell injections?
Dr. Mishra: The medical dictionary definition of a stem
cell has kind of changed. So I think when people use
that, the people who are promoting it sometimes are not
necessarily using it in an appropriate scientific mirror,
basically specialized human cells that can develop into
different cell types.
But I think one thing that's fair to say is that people who
are claiming to inject stem cell preparations are not always
doing that. I don't know all the regulatory parts of it, but (I
do know) the regulatory parts of it in the United States are
different than it is outside the United States. So, people
who truly want stem cell preparation, more often than
not, they're going to be going into Europe or some other
country. Because they are regulated in a very different way
than Platelet-Rich Plasma is.
Answering the other part of your question: from 2006 to
2020, the data is staggering better.
Another important component of the equation that's
important to understand is not all PRP is the same. I'll see
people for second opinions who've been somewhere else
and (I'll ask), 'What'd you have?' And they're like, 'Well, I
had PRP.' Well, what type of PRP? And the reason that's
important is the different types of PRP function differently.
When you talk about attracting stem cells.
TC: At first, I looked at PRP and stem cell injections as,
'Is it like Pepsi and Coke, " or something to that end. Now it
seems like PRP is on a totally different level. Like you said,
there are multiple different types of PRP injections.
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