The Column - May 2007 - (Page 18)

Market Trends and Analysis The Column www.thecolumn.eu.com May 2007 Market Profile: Chiral HPLC Columns A look at the latest global trends in chiral technology. Chiral technology has become a very important aspect for scientists involved in the pharmaceutical, chemical and agricultural industry. The chiral enantiomers can have vitally different pharmacological effects in biological systems. In fact, the US Food and Drug Administration (FDA) mandates that only therapeutically active isomers must be introduced to the prescription drug market. 2007 Chiral HPLC column demand by industry Separation of chiral compounds is typically performed using capillary electrophoresis and chromatographic techniques such as HPLC, GC and SFC. Scientists might also use a variety of methods to analyse stereoisomers such as polarimetry, NMR and calorimetry. In HPLC, there are basically five types of chiral stationary phases including macrocyclic glycopeptides, cyclodextrins, cellulose/amylose, small molecule and proteins, which are typically bonded to silica. The elution order of chiral compounds depends on the formation of transient diastereoisomers because of the interaction with the column packing. The compound that forms the less stable diastereoisomer will elute first. Chiral chemists can use different solvents, additives and/or alter parameters like pH to increase resolution. Temperature plays a key role in separation of chiral compounds. Generally, if the temperature is low enough, it will increase the chiral recognition. However, a temperature that is too low will affect the kinetics of the compound and cause peaks to broaden. Depending on the class of compounds to be separated, there is often a temperature standard that scientists follow. According to SDi’s estimates, the 2007 market for HPLC chiral columns is about $30–50 million. The pharmaceutical industry is responsible for the majority of the market and is expected to drive future growth. Applications in agriculture and chemical markets also fuel demand. Data was extracted and adapted from SDi’s High Performance Liquid Chromatography: New Opportunities in a Reinvigorated Market report. For more information, contact Glenn Cudiamat, vice-president of Research Services, Strategic Directions International, Inc., 6242 Westchester Parkway, Suite 100, Los Angeles, California 90045, USA, tel: + 1 310 641 4982, fax: + 1 310 641 8851, e-mail: cudiamat@strategic-directions.com, website: www.strategic-directions.com 18 Author: Glenn Cudiamat E-mail: cudiamat@strategic-directions.com http://www.thecolumn.eu.com http://www.strategic-directions.com

Table of Contents for the Digital Edition of The Column - May 2007

Contents
News
Using LC–MS to Extend the Time Window for Detecting Drugs
Zosimus
Market Trends and Analysis
Etched Chemically Modified Capillaries: Novel Separation Medium for Electrophoretic Analyses
Q&A
Shaping the Future
Special Section: Shidadzu - LC World Talk

The Column - May 2007