Diabetes Pro Quarterly - Winter 2018 - 16
RESEARCH NEWS
Pathway Awardees continued from page 15
2018 Visionary Awards
Exploring a Novel Gene Therapy
Approach for Diabetes
Samie R. Jaffrey, MD, PhD
Weill Cornell Medicine, New York, NY
Project Title: Rewiring cellular metabolic
networks in diabetes
Diabetes is associated with highly complex
changes in cellular metabolism. Dr. Jaffrey seeks to develop a
new type of gene therapy that will change gene expression in
diabetes-affected cells and tissues. The approach involves
expressing a new class of RNA molecules that function as
molecular devices that perform corrective therapeutic actions,
including sensing glucose and inducing insulin and glucagon-like peptide-1 production; inhibiting insulin resistance; and
suppressing glucose production from the liver. The therapeutic
devices will be tested in animal models of diabetes to provide
critical proof-of-principle data needed to move toward human
gene therapy trials to alleviate the burden of diabetes.
Cellular Changes Associated with Type 1
Diabetes and Type 2 Diabetes
Jonathan V. Sweedler, PhD
University of Illinois, Champaign, IL
Project Title: Unraveling diabetes
progression a cell at a time
Pancreatic islets play critical roles in both
type 1 and type 2 diabetes. Subtypes of pancreatic β-cells are
known to respond differently to chemical signals, and Dr.
Sweedler seeks to understand how these cellular differences influence chemical signaling in diabetes. By understanding changes
that occur during disease progression, we will gain insight into
the chemical mechanisms surrounding β-cell destruction in type
1 diabetes and insulin resistance and subsequent loss of β-cell
function in type 2 diabetes. The project will use advanced technologies to determine the differences between individual human
islet cells affected by type 1 diabetes or type 2 diabetes. The results
will elucidate new chemical parameters characteristic of each
disease, helping to identify novel therapeutic pathways that can
be exploited for the prevention, treatment, and cure of diabetes.
Association Announces Core Research Program Award Recipients
The following investigators recieved
American Diabetes Association (ADA)
grants beginning in January 2018. In
addition to these research, training, and
development grants, the ADA provided
11 currently funded investigators an
additional $3,000 stipend to support
minority undergraduate students in each
of their laboratories.
Jianchun Chen, MD
Vanderbilt University Medical Center
Alterations of the hippo signaling pathway
in diabetic nephropathy
Research Awards
Young-In Chi, PhD*
University of Minnesota, Twin Cities
Molecular targeting of HNF4alpha
repressive states
Innovative Basic Science Awards
Laura Cristina Alonso, MD
University of Massachusetts Medical
School
T2D risk-SNPs at the CDKN2AB locus
Rebecca L. Berdeaux, PhD
The University of Texas Health Science
Center at Houston
Regulation of mitophagy by SIK1
J. Nicholas Betley, PhD
University of Pennsylvania
Understanding the peripheral regulation
of feeding circuits
Lu Cai, MD, PhD
University of Louisville Research
Foundation, Inc.
Zinc-induced MT prevents diabetic
cardiomyopathy by regulating CARD9/
P38a MAPK
16
Xiaoli Chen, MD, PhD
University of Minnesota
Pentraxin 3 in age-related thermogenic
adipose degeneration and glucose
intolerance
Senad Divanovic, PhD
Cincinnati Children's Hospital Medical
Center
Immune-modulation of obesity
development: a new function for BAFF
Michael S. German, MD
University of California, San Francisco
Exosome therapy for diabetes
Rebecca Anne Haeusler, PhD*
Columbia University
Bile acid composition and glucose
metabolism
Sean Michael Hartig, PhD
Baylor College of Medicine
A microRNA rheostat that regulates
fuel utilization
Janice M. Huss, PhD
Beckman Research Institute of City
of Hope
Estrogen-related receptor alpha mediates
skeletal muscle genetic and metabolic
response to exercise
Konstantin V. Kandror, PhD
Boston University School of Medicine
Regulation of leptin production by
mTORC1
Hon-Chi Lee, MD, PhD
Mayo Clinic, Rochester
Regulation of vascular endothelial ion
channels in diabetes
Wei Li, PhD
University of Miami School of Medicine
A novel disease-selective therapy for
diabetic retinopathy
Feng Liu, PhD
The University of Texas Health Science
Center at San Antonio
Regulation of mitochondrial biogenesis
and function by DsbA-L in the liver
Alexander R. Nectow, PhD
Princeton University
Dissection of a brainstem circuit in obesity
Babak Razani, MD, PhD
Washington University
Harnessing the autophagy-lysosomal
continued on page 17
Table of Contents for the Digital Edition of Diabetes Pro Quarterly - Winter 2018
In This Issue
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