comparison of specific and non-specific analytical methods Specific methods of cleaning validation are intended to detect a single compound of interest such as an active pharmaceutical ingredient (API). This gives a very limited understanding of the cleanliness of a piece of equipment. Degradants, cleaning agents, excipients, or other sources of contamination could be present and left undetected by a specific method of monitoring. With total organic carbon (TOC) and conductivity monitoring, a comprehensive assessment of cleanliness can be used to release equipment confidently. 7