eBook: TOC and Microbial Detection Monitoring - 18

Analytical equipment for Cold WFI production
Innovative METTLER TOLEDO Thornton systems offer the highest quality and reliability for pharmaceutical and biotechnology facilities where compliance, calibration and validation of pharmaceutical water
systems is required.
The METTLER TOLEDO portfolio of on-line sensors and analyzers provides continuous, real-time
monitoring of microbial contamination as well as conductivity and TOC, enabling the required real-time
insight into Cold WFI production.

positions within the RO water system
as determined through quality risk
management principles. "The suggestion from the EMA is for multiple
measurement points for conductivity
and TOC, not just in the return loop to
the storage tank.
The purpose of these multiple measurement points is to develop trend
data that constantly show the status of
the water system for the monitored
parameters, and to be able to develop
appropriate alert and action levels
which permit corrective action before
the system is out-of-specification. As
the EMA says: "The frequency of trend
analysis and use of trend data is critical. The use of rapid microbiological
test methods and systems should be
considered in order to improve or increase the probability of early detection and allow timely action to be
taken."
See METTLER TOLEDO Thornton's solutions for the pharma industry:
c www.mt.com/Thornton

UniCond
conductivity sensors

7000RMS microbial
contamination analyzer

Reduced inventory
Very wide measuring range means
only one sensor model is required

High confidence in water quality
Real-time notification of microbial
excursions

Error-free installation
Plug and Measure feature ensures
easy start-up

Reduced costs
Optimizes sanitization cycles

No measurement interference
Internal measuring circuit and
digital output provide high signal
integrity
c www.mt.com/UniCond

18

Flexible throughout a facility
For use in RO systems, and pure
water storage and distribution loops
c www.mt.com/7000RMS

http://www.mt.com/7000RMS http://www.mt.com/UniCond

eBook: TOC and Microbial Detection Monitoring

Table of Contents for the Digital Edition of eBook: TOC and Microbial Detection Monitoring