Contents 4 Batch or Continuous: Real-time TOC measurement Real time compliance TOC systems from METTLER TOLEDO Thornton enable continuous assurance through unique, real-time measurement systems with complete confidence in compliance. Confidence is maintained by engineering systems to address all globally recognized requirements of regulated waters and providing continuous measurements to prevent undetected issues from shutting down production. 10 Simplifying the Regulations for TOC in Pharmaceutical Waters Pharmaceutical manufacturers are faced with an evergrowing list of resources that aim to define or assist with the interpretation of regulatory guidance. It is critical to understand how these resources apply to specific parameters, analytical instruments, and analytical methods when defining the approach for a given manufacturing process. This paper brings clarity to the applicability of these resources, with a specific example demonstrating a method for continuous Total Organic Carbon (TOC) monitoring of Bulk Pharmaceutical Waters. 16 5 Ways to Optimize Water Monitoring 28 Total Organic Carbon Sensor Top Performance and Easy Installation 30 Hot Water For Injection Biofilm, Endotoxins and Their Relationship 35 Real-time Microbial Detection Enables True Water System Surveillance for Better Process Control and Risk Reduction 38 Bioburden Analysis for Process Control Reduces Plate Counting Costs and Delays 2