eBook: TOC and Microbial Detection Monitoring - 25

Confirm Complete Sanitization

Confirm Water System Sanitization
with Reliable Ozone Measurement
Ozone is being increasingly used in the sanitization of pharma water systems.
The new pureO3® sensor provides fast, dependable measurements plus the
lower operating cost benefits of Intelligent Sensor Management.

A natural and powerful oxidizer
Dissolved ozone, a naturally occurring
form of oxygen, is one of the most
aggressive oxidizers used to manage
and control biological contamination
in Pharmaceutical and Life Science
water systems. Ozone is an effective
oxidant that quickly destroys biofilm
and aqueous microbial contamination
with low, easy-to-control dosages and
minimal contact time. The molecule's
very short half-life is typically accelerated with exposure to UV light (at

254 nm wavelength) leaving no residual chemicals or traces of ozone
after sanitization, and meeting the "no
added substances" regulation.

Control of biological
contamination is mandatory
Microbiological monitoring and control is required for regulated waters
globally. Purified Water (PW) and
Water For Injection systems operators
diffuse ozone gas into their water loops
at the precise quantities needed to

sanitize the system to protect against
contamination. Once sanitization is
complete, the remaining ozone gas is
destroyed using UV light. Monitoring
and control are required to limit the
total ozone gas levels needed for
sanitization (100 - 150 ppb) and also
to confirm that all ozone gas is removed from the water system after
sanitization and prior to release. Ozone
monitoring and analysis manages this
process precisely and provides an

pureO3 Ozone Sensor
* High accuracy at very low ppb
ozone concentrations
* Reinforced silicone membrane
for exceptional durability and
repeatability
* Fast response: 30 seconds for
90%
* Plug and Measure start up
* Advanced predictive diagnostics with ISM

10

METTLER TOLEDO Pharmaceutical Waters

25
eBook: TOC and Microbial Detection Monitoring

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