eBook: TOC and Microbial Detection Monitoring - 9

Real-Time Compliance

Global guidelines are firmly established to verify oxidation efficiency of TOC analyzers in regulated water systems. In the United
States, these guidelines are documented in the USP test chapter
<643> TOTAL ORGANIC CARBON. TOC analyzers must periodically meet a System Suitability Testing (SST) requirement. System
Suitability Testing challenges TOC instruments by verifying system responsiveness against two types of known organic chemicals.
USP <643> specifies these two compounds are sucrose and
1,4-benzoquionone. Due to their different chemical structure,
these compounds challenge the bond-breaking and oxidation capability of the TOC measurement technology. Systems which pass
SST are confirmed to have sufficient oxidation and are found
suitable for continued regulatory water monitoring. USP <643>
and EP 2.2.44 require that the SST test be performed periodically
on a calibrated instrument. All METTLER TOLEDO Thornton TOC
sensors are engineered to meet these requirements and have procedures for conducting SST.

Summary
Compliance with global regulatory requirements is assured with
TOC systems from METTLER TOLEDO Thornton. Continuous flow
and measurement ensures upset conditions are not missed and
detected early removing uncertainty. Systems are fully compliant
for their intended use with global agencies such as USP, EP, ChP,
and JP. The unique quartz flow-coil design maximizes light absorbance from a high-power lamp source for quick responsiveness
and oxidation fully compliant with SST requirements. Real-time,
on-line TOC measurements from METTLER TOLEDO provide
Pharmaceutical regulated water systems the greatest confidence in
maintaining compliance

Portable and at-line TOC systems

Literature References
1. DeDona Giovanni, Theriault, Robert: Improving Water System
Performance: A Continuous TOC Measurement Technology to Enhance
Real-Time Process Control, Pharmaceutical Engineering, 2008.

VIDEO: Batch or Continuous, Real-Time TOC Measurement: What Can
www.mt.com/TOC
Happen
in 6 Minutes? 6000TOCi
This video demonstrates how the at-line batch method of
monitoring total organic carbon (TOC), which takes measurements at set intervals, is the equivalent of taking snapshots of information. The gaps between measurement intervals could easily miss a critical event, whereas on-line,
continuous TOC monitoring captures any-and-all excursions in real-time.
METTLER TOLEDO Group
Process Analytics Division
Local contact: www.mt.com/contacts

Subject to technical changes
©07/2019 METTLER TOLEDO. All rights reserved
Rev B 7/2019

www.mt.com/pro
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eBook: TOC and Microbial Detection Monitoring

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