The ASHA Leader - February 2015 - (Page 17)
research in brief
Chemical May Prevent Noise-Induced Hearing Loss
Researchers have found a way to
prevent noise-induced hearing loss
in a mouse using a simple chemical
compound that is a precursor to
vitamin B3. This discovery from
the University of North Carolina's
Weill Cornell Medical College and
the Gladstone Institutes, published
in Cell Metabolism (bit.ly/nihlprevention), holds implications
for preventing hearing loss and
for treating some aging-related
conditions linked to the same
protein.
Led by Kevin Brown, an associate
professor of otolaryngology-head
and neck surgery at the University of
North Carolina School of Medicine,
the researchers used the chemical
nicotinamide riboside to protect
the nerves used to transmit sound
information from the cochlea to
the spiral ganglion, which then
passes those messages to the brain.
Exposure to loud noises damages
the synapses connecting the nerves
and the hair cells in the cochlea,
resulting in noise-induced hearing
loss.
The researchers gave mice NR
before or after exposing them to
loud noises. NR was successful at
preventing damage to the synaptic
connections and avoiding both
short-term and long-term hearing
loss-regardless of whether it was
given before or after the noise
exposure. NR can be taken orally
and readily enters cells.
The researchers think the results
may have broader applications
beyond preventing hearing loss
because of the way NR protects
nerve cells: It increases the activity
of SIRT3, a protein critical to
the function of mitochondria,
the powerhouses of the cell. This
enhanced SIRT3 may be the reason
for the protective properties of NR.
To test this, they deleted the SIRT3
gene in mice, which abolished the
NR protective properties. SIRT3
decreases naturally with age, which
could partially explain aging-related
hearing loss. These results suggest
that using NR could be a viable
target for treating a variety of
aging-related disorders in addition
to hearing loss, including metabolic
syndromes associated with obesity,
pulmonary hypertension and
diabetes.
ยป Read more research briefs at
leader.pubs.asha.org.
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le ader .pubs. asha .org
17
http://www.bit.ly/nihl-prevention
http://www.bit.ly/nihl-prevention
http://leader.pubs.asha.org
http://www.speechvive.com
http://www.speechvive.com
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The ASHA Leader - February 2015
Table of Contents for the Digital Edition of The ASHA Leader - February 2015
Contents
The ASHA Leader - February 2015 - Intro
The ASHA Leader - February 2015 - Cover1
The ASHA Leader - February 2015 - Cover2
The ASHA Leader - February 2015 - Contents
The ASHA Leader - February 2015 - 2
The ASHA Leader - February 2015 - 3
The ASHA Leader - February 2015 - 4
The ASHA Leader - February 2015 - 5
The ASHA Leader - February 2015 - 6
The ASHA Leader - February 2015 - 7
The ASHA Leader - February 2015 - 8
The ASHA Leader - February 2015 - 9
The ASHA Leader - February 2015 - 10
The ASHA Leader - February 2015 - 11
The ASHA Leader - February 2015 - 12
The ASHA Leader - February 2015 - 13
The ASHA Leader - February 2015 - 14
The ASHA Leader - February 2015 - 15
The ASHA Leader - February 2015 - 16
The ASHA Leader - February 2015 - 17
The ASHA Leader - February 2015 - 18
The ASHA Leader - February 2015 - 19
The ASHA Leader - February 2015 - 20
The ASHA Leader - February 2015 - 21
The ASHA Leader - February 2015 - 22
The ASHA Leader - February 2015 - 23
The ASHA Leader - February 2015 - 24
The ASHA Leader - February 2015 - 25
The ASHA Leader - February 2015 - 26
The ASHA Leader - February 2015 - 27
The ASHA Leader - February 2015 - 28
The ASHA Leader - February 2015 - 29
The ASHA Leader - February 2015 - 30
The ASHA Leader - February 2015 - 31
The ASHA Leader - February 2015 - 32
The ASHA Leader - February 2015 - 33
The ASHA Leader - February 2015 - 34
The ASHA Leader - February 2015 - 35
The ASHA Leader - February 2015 - 36
The ASHA Leader - February 2015 - 37
The ASHA Leader - February 2015 - 38
The ASHA Leader - February 2015 - 39
The ASHA Leader - February 2015 - 40
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The ASHA Leader - February 2015 - 71
The ASHA Leader - February 2015 - 72
The ASHA Leader - February 2015 - Cover3
The ASHA Leader - February 2015 - Cover4
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