ASH News Daily 2014 - Day 4 - (Page A-1)
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www.hematology.org/ashnewsdaily2014_tuesday
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Schedule
7:00 a.m. - 1:30 p.m.
Registration
Moscone West, Lobby - First Floor
7:15 - 9:15 a.m.
Special Symposium on the Basic
Science of Hemostasis and
Thrombosis*
(invited presentations)
Moscone North, Rooms 120-125)
7:30 - 9:00 a.m.
Simultaneous Oral Sessions
7:30 - 9:00 a.m.
Late-Breaking Abstracts Session
Moscone North, Hall D
9:30 - 9:45 a.m.
Announcement of Awards
Dameshek Prize, Stratton Medal,
and Mentor Award
Moscone North, Hall D
9:45 - 11:15 a.m.
Presidential Symposium
Moscone North, Hall D
11:15 - 11:45 a.m.
Business Meeting
Moscone North, Hall D
11:30 noon - 1:00 p.m.
Best of ASH
Moscone North, Hall D
IN THIS SECTION
Choosing Wisely
A-2
Presidential Symposium
A-3
Checkpoint Blockades
A-5
Late Breaking Abstracts
A-7
Iron and Its Strange Bedfellows
By John J. StrouSe, Md, Phd
Y
esterday morning, ASH honored Dr. Tomas Ganz from
the University of California,
Los Angeles, with the E. Donnall
Thomas Lecture. Dr. Ganz is known
for his earth-shaking research in
iron homeostasis and after an introduction by ASH President, Dr.
Linda Burns, Dr. Ganz presented
his enthralling lecture on the sexy
story of entanglement between iron,
erythropoiesis, and host defense
and did not disappoint. The plot began with the history of the study of
iron in medicine and its important
role in human health and disease.
Dr. Ganz then focused on the explosion in our understanding of the
molecular underpinnings of iron
metabolism and iron homeostasis at
the level of the organism and cell.
Dr. Ganz is well recognized for
his isolation (from many gallons of
urine) and characterization of hepcidin, a master regulator of iron homeostasis that Dr. Ganz describes as
follows: "Hepcidin is to iron as insulin is to glucose." The propeptide
of hepcidin is made and secreted by
hepatocytes and then cleaved to the
active 25 amino acid form by furin.
In the discussion, Dr. Ganz reviewed
the role of hepcidin in both the regulation of intestinal iron absorption
»» IRON Page A-4
Sickle Cell Disease: An Unfinished Jigsaw Puzzle
By IfeyInwa (Ify) oSunkwo, Md,
MPh
S
ickle cell disease (SCD) was
first reported in 1910 in a dental student who presented
with recurrent episodes of pain and
anemia. Since that time, researchers
and clinicians have struggled to understand the complex mechanisms
responsible for the heterogeneous
manifestations of this disease.
Yesterday, Dr. Michael DeBaun of
Vanderbilt University School of
Medicine in Nashville and Dr. Robert Hebbel of the University of Minnesota in Minneapolis presented
Dr. Michael DeBaun delivers his half of
the Ernest Beutler Lecture Monday. DeBaun appears in front of a slide of "Ten
Redefined," a sickle cell pain awareness painting created by Haitian artist
Hertz Nazaire. Dr. Robert Hebbel also
received this year's prize and delivered
the other half of the lecture.
the 2014 Ernest Beutler Lecture in
recognition of their revolutionary
contributions toward the science
and clinical treatment of SCD. This
award was established to honor
two outstanding individuals who
have advanced the field of hematology in the areas of basic science
and clinical translational research.
Starting the session "Sickle Cell
Anemia: Improved Understanding
but Continued Challenges" Dr. DeBaun presented outcomes of sentinel SCD clinical trials including his
work on understanding the epidemiology and treatment of silent cerebral infarcts. Dr. DeBaun showed
data that 30 percent of school-age
children have silent cerebral infarcts
that are associated with a mean
five-point reduction in IQ points
that progresses over time. Bringing
the conversation to a more global
level, he reminded the audience
»» PUZZLE Page A-4
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ASH News Daily 2014 - Day 4
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