ASH News Daily 2015 - Day 4 - (Page A-1)
ASH NEWS DAILY
®
57th Annual Meeting of the American Society of Hematology
Issue 4, Section A
Tuesday, December 8, 2015
Orlando, FL
Read this issue online at
www.hematology.org/ashnewsdaily2015_tuesday
Follow us on Twitter using #ASH15
SCHEDULE
Clot Prevention by Apples and Onions? The
PDI Story in Full Color
BY JEANNE PALMER, MD
7:00 a.m. - 1:30 p.m.
Registration
Orange County Convention Center
West Building, Level 1 Concourse
7:30 - 9:30 a.m.
Late-Breaking Abstracts Session
Orange County Convention Center
(Hall D)
9:30 - 9:45 a.m.
Announcement of Awards:
William Dameshek Prize,
Henry M. Stratton Medal
Orange County Convention Center
(Hall D)
9:45 - 11:15 a.m.
Presidential Symposium
Orange County Convention Center
(Hall D)
11:15 - 11:30 a.m.
Business Meeting
Orange County Convention Center
(Hall D)
11:30 a.m. - 1:00 p.m.
Best of ASH
Orange County Convention Center
(Hall D)
O
n Monday, ASH honored
Barbara Furie, PhD, and
Bruce Furie, MD, with the E.
Donnall Thomas Lecture and Prize
for their groundbreaking research
in hemostasis and thrombosis. They
presented their lecture, titled "Thiol
Isomerases as Potential Regulators
Controlling the Initiation of Thrombus Formation," in a morning general session. Dr. Bruce Furie is the
chief of hemostasis-thrombosis at
Beth Israel Deaconess Medical Center, the director of the Blood Coagulation and Vascular Biology Training
Program, and professor of medicine
at Harvard Medical School. Dr. Barbara Furie is professor emeritus
at Harvard Medical School. They
have been involved in hemostasis
and thrombosis research since the
1970s and have achieved a number
of impressive accomplishments, including the role of thiol isomerases
in thrombus formation, which was
discussed today.
Drs. Barbara and Bruce Furie
did not anticipate developing a
career in hematology. At 16 years
of age, Dr. Bruce Furie founded a
summer sailing school and a sail-
boat rental agency, Furie Sailing, on
Long Beach Island in New Jersey.
He had more than 40 rental boats
and taught thousands how to sail.
»» FURIES Page A-5
Keep Calm, It's Just the Proteasome
BY SAAD USMANI, MD
T
IN THIS SECTION
Late-Breaking
A-2
Childhood ALL
A-3
Immunotherapy
A-4
Health-care Costs
A-7
Dr. Alfred Goldberg
he proteasome has been likened to the garbage disposal
unit of the cell. It "grinds"
down ubiquinated protein that is no
longer needed by the cell into tiny
bits, readying them for elimination. There are many moving parts
to the proteasome machinery, and
they all work together to maintain
protein homeostasis. Since its discovery in the 1980s, the proteasome
has emerged as an attractive targeted therapy in cancer in general
and multiple myeloma specifically.
This year's Ernest Beutler Lecture
and Prize was awarded to Dr. Paul
Richardson of Dana-Farber Cancer
Institute and Dr. Alfred Goldberg of
Harvard Medical School. On Monday, they presented their lecture,
"Understanding the Proteasome:
From Protein Degradation to Disease
Therapy." They are being recognized
for their noteworthy research discoveries in the area of proteasome inhibitors and their development as novel
therapies for multiple myeloma.
Dr. Goldberg is professor of cell
biology at Harvard Medical School.
He is an elected member of the National Academy of Sciences and the
American Academy of Arts and
Sciences, as well as a fellow of the
American Association for the Advancement of Science. His efforts
have spanned more than three decades and have been pivotal in
understanding normal plasma cell
biology and the role of the proteasome/ubiquitination pathway.
During the lecture, he shared his
own narrative - a scientific and
professional journey that epitomizes bench-to-bedside research.
He discussed the rationale for developing proteasome inhibition as
»» BEUTLER Page A-4
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ASH News Daily 2015 - Day 4
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