ASH News Daily 2017 - Issue 3 - B-34
ASH News Daily
Page B-34
Monday, December 11, 2017
®
Stratton Medal
«« From Page B-20
methods for blood cell lineage separation, and ability to culture and
analyze the purified cell lineages for
their protein and other components.
While his major interest was to define a blood disease phenotype and
establish its molecular basis, his experience with assaying G6PD deficiency and studying G6PD polymorphisms led him to extend his studies
to the clonality of blood diseases,
the hierarchy of hematopoiesis, and
clonal selection of X-chromosome-
inherited diseases such as Wiscott-
Aldrich syndrome. "This ultimately
led me to focus on uncovering the
molecular basis of novel congenital
disorders," he said, "including those
of the red cell membrane, hemoglobin, and eventually polycythemic
disorders."
Of his extensive work, Dr. Prchal
is most proud of the discovery of
the molecular basis of the first congenital disorder of hypoxia sensing
- Chuvash polycythemia. This accomplishment taught him the importance of collaboration, working
alongside Dr. Victor Gordeuk. Dr.
Prchal overcame his initial skepticism that von Hippel Lindau (VHL)
mutations were a cause of polycythemia when they found with a link
to the VHL gene, since mutations
of that gene were well established
as the cause of several cancers. Yet,
they discovered that individuals
with Chuvash polycythemia have
erythrocytosis and thromboses, but
no VHL tumors. "I realized that in
complex tasks it is essential to recruit collaborators with the skills
and ability I do not have..." he stated. "It increases the efficiency of any
research endeavor."
Dr. Prchal recognizes that while
they have yet to fully understand
the pathophysiological consequenc-
YOUR SOURCE FOR WORLDWIDE NEWS AND
PERSPECTIVES IN HEMATOLOGY/ONCOLOGY
"I realized that in
complex tasks it is
essential to recruit
collaborators with the
skills and ability I do not
have...It increases the
efficiency of any
research endeavor."
- Dr. Prchal
es of the homozygous Chuvash
polycythemia VHL mutations that
cause an augmented response to a
multitude of physiological responses to hypoxia, they must also focus
on comprehending the evolutionary
heterozygote advantage of Chuvash
polycythemia mutation. Additionally, Dr. Prchal mentions that difficulties remain in obtaining funding
to pursue research of exciting novel
ideas.
Aside from understanding the
importance of collaboration, Dr. Prchal also highlights the importance
of mentorship. "Drs. Ernest Beutler
and Y.W. Kan both advised me that
the best way of understanding physiology and pathophysiology and
advancing knowledge of biology is
to uncover the molecular basis and
detailed inheritance of human blood
diseases," he recalled, mentioning
that they were always available to
discuss his questions, regardless of
how naïve they seemed. Dr. Prchal
is grateful to his mentors and hopes
that he can repay his debt to them
by encouraging younger colleagues
to pursue their own intellectual inquiries, stressing that there is much
to learn and discover when it comes
to disease pathophysiology.
New This Year:
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✓ Insightful editorials and in-depth feature articles
✓ Coverage of practice-changing research
✓ Interviews with innovators and mentors in hematology
✓ Challenging clinical cases - answered by experts
(and our readers!)
Pick up a copy in one of the bins located throughout
the convention center.
ashclinicalnews.org | @ASHClinicalNews
A new taxonomy of common
keywords applied to individual presentations within the Education Program, Scientific Program, Special-Interest Sessions,
and Oral Abstract Sessions will
help you identify talks and sessions related to your specific interests. In addition to the standard keyword search, you can
now refine your resulting list
of presentations with a second
layer of keyword options. The
search features are available on
the ASH website, but we recommend that you download
the annual meeting mobile app
for optimal search functionality; you can search by disease,
therapy type, mechanism, technology/procedure, and study
population.
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Table of Contents for the Digital Edition of ASH News Daily 2017 - Issue 3
ASH News Daily 2017 - Issue 3 - A-1
ASH News Daily 2017 - Issue 3 - A-2
ASH News Daily 2017 - Issue 3 - A-3
ASH News Daily 2017 - Issue 3 - A-4
ASH News Daily 2017 - Issue 3 - A-5
ASH News Daily 2017 - Issue 3 - A-6
ASH News Daily 2017 - Issue 3 - A-7
ASH News Daily 2017 - Issue 3 - A-8
ASH News Daily 2017 - Issue 3 - A-9
ASH News Daily 2017 - Issue 3 - A-10
ASH News Daily 2017 - Issue 3 - A-11
ASH News Daily 2017 - Issue 3 - A-12
ASH News Daily 2017 - Issue 3 - A-13
ASH News Daily 2017 - Issue 3 - A-14
ASH News Daily 2017 - Issue 3 - A-15
ASH News Daily 2017 - Issue 3 - A-16
ASH News Daily 2017 - Issue 3 - A-17
ASH News Daily 2017 - Issue 3 - A-18
ASH News Daily 2017 - Issue 3 - A-19
ASH News Daily 2017 - Issue 3 - A-20
ASH News Daily 2017 - Issue 3 - A-21
ASH News Daily 2017 - Issue 3 - A-22
ASH News Daily 2017 - Issue 3 - A-23
ASH News Daily 2017 - Issue 3 - A-24
ASH News Daily 2017 - Issue 3 - A-25
ASH News Daily 2017 - Issue 3 - A-26
ASH News Daily 2017 - Issue 3 - A-27
ASH News Daily 2017 - Issue 3 - A-28
ASH News Daily 2017 - Issue 3 - B-1
ASH News Daily 2017 - Issue 3 - B-2
ASH News Daily 2017 - Issue 3 - B-3
ASH News Daily 2017 - Issue 3 - B-4
ASH News Daily 2017 - Issue 3 - B-5
ASH News Daily 2017 - Issue 3 - B-6
ASH News Daily 2017 - Issue 3 - B-7
ASH News Daily 2017 - Issue 3 - B-8
ASH News Daily 2017 - Issue 3 - B-9
ASH News Daily 2017 - Issue 3 - B-10
ASH News Daily 2017 - Issue 3 - B-11
ASH News Daily 2017 - Issue 3 - B-12
ASH News Daily 2017 - Issue 3 - B-13
ASH News Daily 2017 - Issue 3 - B-14
ASH News Daily 2017 - Issue 3 - B-15
ASH News Daily 2017 - Issue 3 - B-16
ASH News Daily 2017 - Issue 3 - B-17
ASH News Daily 2017 - Issue 3 - B-18
ASH News Daily 2017 - Issue 3 - B-19
ASH News Daily 2017 - Issue 3 - B-20
ASH News Daily 2017 - Issue 3 - B-21
ASH News Daily 2017 - Issue 3 - B-22
ASH News Daily 2017 - Issue 3 - B-23
ASH News Daily 2017 - Issue 3 - B-24
ASH News Daily 2017 - Issue 3 - B-25
ASH News Daily 2017 - Issue 3 - B-26
ASH News Daily 2017 - Issue 3 - B-27
ASH News Daily 2017 - Issue 3 - B-30
ASH News Daily 2017 - Issue 3 - B-31
ASH News Daily 2017 - Issue 3 - B-32
ASH News Daily 2017 - Issue 3 - B-33
ASH News Daily 2017 - Issue 3 - B-34
ASH News Daily 2017 - Issue 3 - B-35
ASH News Daily 2017 - Issue 3 - B-36
ASH News Daily 2017 - Issue 3 - B-37
ASH News Daily 2017 - Issue 3 - B-38
ASH News Daily 2017 - Issue 3 - B-39
ASH News Daily 2017 - Issue 3 - B-40
ASH News Daily 2017 - Issue 3 - B-41
ASH News Daily 2017 - Issue 3 - B-42
ASH News Daily 2017 - Issue 3 - B-43
ASH News Daily 2017 - Issue 3 - B-44
ASH News Daily 2017 - Issue 3 - B-45
ASH News Daily 2017 - Issue 3 - B-46
ASH News Daily 2017 - Issue 3 - B-47
ASH News Daily 2017 - Issue 3 - B-48
ASH News Daily 2017 - Issue 3 - B-49
ASH News Daily 2017 - Issue 3 - B-50
ASH News Daily 2017 - Issue 3 - B-51
ASH News Daily 2017 - Issue 3 - B-52
ASH News Daily 2017 - Issue 3 - B-53
ASH News Daily 2017 - Issue 3 - B-54
ASH News Daily 2017 - Issue 3 - B-55
ASH News Daily 2017 - Issue 3 - B-56
ASH News Daily 2017 - Issue 3 - C-1
ASH News Daily 2017 - Issue 3 - C-2
ASH News Daily 2017 - Issue 3 - C-3
ASH News Daily 2017 - Issue 3 - C-4
ASH News Daily 2017 - Issue 3 - C-5
ASH News Daily 2017 - Issue 3 - C-6
ASH News Daily 2017 - Issue 3 - C-7
ASH News Daily 2017 - Issue 3 - C-8
ASH News Daily 2017 - Issue 3 - C-9
ASH News Daily 2017 - Issue 3 - C-10
ASH News Daily 2017 - Issue 3 - C-11
ASH News Daily 2017 - Issue 3 - C-12
ASH News Daily 2017 - Issue 3 - C-13
ASH News Daily 2017 - Issue 3 - C-14
ASH News Daily 2017 - Issue 3 - C-15
ASH News Daily 2017 - Issue 3 - C-16
ASH News Daily 2017 - Issue 3 - C-17
ASH News Daily 2017 - Issue 3 - C-18
ASH News Daily 2017 - Issue 3 - C-19
ASH News Daily 2017 - Issue 3 - C-20
ASH News Daily 2017 - Issue 3 - C-21
ASH News Daily 2017 - Issue 3 - C-22
ASH News Daily 2017 - Issue 3 - C-23
ASH News Daily 2017 - Issue 3 - C-24
ASH News Daily 2017 - Issue 3 - C-25
ASH News Daily 2017 - Issue 3 - C-26
ASH News Daily 2017 - Issue 3 - C-27
ASH News Daily 2017 - Issue 3 - C-28
ASH News Daily 2017 - Issue 3 - C-29
ASH News Daily 2017 - Issue 3 - C-30
ASH News Daily 2017 - Issue 3 - C-31
ASH News Daily 2017 - Issue 3 - C-32
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