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Translation of RNA Medicines from Design to Clinic
Translation of RNA Medicines
from Design to Clinic
During development of pharmaceutically-applicable
mRNA therapeutics, synthesis, optimization, and
formulation must be taken into consideration.
RNA therapeutics comprise a rapidly expanding
category of drugs that will speed clinical
solutions, actualize personalized medicine, and
make the term " undruggable " obsolete, according
to a March 2021 Frontiers in Bio-engineering
and Biotechnology review.1 Different classes
of RNA-based therapeutics include antisense
oligonucleotides, aptamers, small interfering
RNAs, microRNAs, and messenger RNA (mRNA).
The widespread use of mRNA vaccines
24 | GENengnews.com
for COVID-19 marked 2020 as a breakout
year for mRNA technology platforms.
mRNA therapeutics are applicable to cancer
immunotherapies, infectious diseases, and other
indications that require protein replacement
therapy or antibodies. After cellular uptake, the
therapeutic molecule translates genetic information
into protein, an antigen, antibody, or other
therapeutic protein. During development of the
therapeutics several aspects must be taken into

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Cytiva_Jan2022_mRNAVaccinesANewEra

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