Isoplexis_July2021_AcceleratingDevelopmentCurativeMedicines - 12

ACCELERATING THE DEVELOPMENT OF CURATIVE MEDICINES WITH FUNCTIONAL IMMUNE PROFILING
Resolving Challenges of Oncolytic
Immunotherapy Delivery to Disrupt
the Tumor Microenvironment with
Functional Single-Cell Proteomics
I
soPlexis' immune profiling has also generated key
predictive insights in cancer immunology across
many high-impact publications. In one study
published in Molecular Therapy, the Single-Cell Secretome
solution was used to assess the efficacy of a
novel delivery system for CAR-T cells with the potential
to be highly effective against solid tumors.
One challenge in treating solid tumors with
12 | GENengnews.com
adoptive cell therapies is that the complexities of the
tumor microenvironment (TME) can create a barrier
to effective treatment, like limiting the infiltration of
CAR-T cells. The TME produces immune-inhibitory
ligands, cytokines, and chemokines, which inhibit
cytotoxic T cell responses. Thus, the identification of
therapies that can disrupt the TME while promoting
functional drivers of T cell persistence is a significant
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Isoplexis_July2021_AcceleratingDevelopmentCurativeMedicines

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