Origene_Jan2021_ProperAntibodyDesignKeeps - 14

Coronavirus-Neutralizing Human Antibody Discovered

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47D11 neutralizes SARS-CoV and SARS-CoV-2

Wang, PhD, founder, Chairman & Chief Executive

through " a yet unknown mechanism " that is

Officer of HBM. " Much more work is needed to

different from receptor-binding interference. " Alter-

assess whether this antibody can protect or reduce

native mechanisms of coronavirus neutralization

the severity of disease in humans. We expect to

by RBD-targeting antibodies have been reported

advance development of the antibody with part-

including spike inactivation through antibody-in-

ners. We believe our technology can contribute to

duced destabilization of its prefusion structure,

addressing this most urgent public health need and

which may also apply for 47D11, " the team noted.

we are pursuing several other research avenues. " ●

" In conclusion, this is the first report of a
(human) monoclonal antibody that neutralizes
SARS-CoV-2, " they concluded. " This antibody will
be useful for development of antigen detection
tests and serological assays targeting SARS-CoV-2
... this antibody-either alone or in combination-offers the potential to prevent and/or treat

Need antibodies against SARSCOV2 or ACE2, including the
neutralizing antibodies?
Request
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COVID-19, and possibly also other future emerging
diseases in humans caused by viruses from the
Sarbecovirus subgenus. "
" This is groundbreaking research, " said Jingsong

14 |

GENengnews.com

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