Origene_Jan2021_ProperAntibodyDesignKeeps - 4

Proper Antibody Design Keeps Specificity In Mind

INTRODUCTION

modifications of the native protein. Antibodies
atural antibodies are an amazing design

generated against such immunogen can fail to

of nature. Our immune system produces

recognize native proteins. Additionally, synthetic

proteins of unique structure to bind

peptides do not carry post-translational modifica-

specifically to incoming foreign agents and protect

tions and, therefore, can miss critical epitopes.

our body from exogenous invaders. Human ingenuity takes the lesson from nature, turning anti-

On the other hand, full-length proteins made from

bodies into one of the most useful and versatile

human cells are the best immunogen to generate

types of tools for life science research, clinical

highly specific and functional antibodies that

diagnostics, and even therapeutics. The impact of

recognize native protein targets. This is precisely

antibodies has dramatically expanded with recent

what OriGene offers-as our TrueMABs are mouse

advancements.

monoclonal antibodies made using full-length
human proteins expressed in a human cell as the

SPECIFICITY! SPECIFICITY! SPECIFICITY!

immunogen. Although this is a slower and more
expensive way to make antibodies, we believe this

When an antibody is used in a research applica-

is the method that produces a higher quality, more

tion or clinical tests, one of the essential features to

specific antibody. OriGene has accumulated over

be critically evaluated is its specificity. Specificity

12,000 TrueMABs, and assay developers are discov-

addresses whether the antibody can uniquely bind

ering new benefits of using TrueMABs all the time.

its intended target while ignoring other similar
targets. Promiscuous binding of antibodies can
cause misleading results in research and erroneous

Why is TrueMAB is the
right antibody?

diagnoses of clinical tests.

Watch a 2-min video

So, how then do we make antibodies with high
specificity? One of the solutions is to use an
extremely unique immunogen. While synthetic
peptides are commonly used as immunogens for
quick antibody generation, they tend not to recapitulate the 3D structure or post-translational

GENengnews.com

https://www.youtube.com/watch?v=T71NRH3F4Vc&feature=youtu.be http://www.GENengnews.com

Origene_Jan2021_ProperAntibodyDesignKeeps

Table of Contents for the Digital Edition of Origene_Jan2021_ProperAntibodyDesignKeeps