Clinical OMICs - Volume 3, Issue 4 - (Page 5)

Molecular Diagnostics in Personalized Medicine Genomics is refining its tradecraft and upgrading its analysis, as it must if it is to succeed in rolling up the active networks and sleeper cells behind cancer. FINER CANCER SCREENS CATCH MORE CANCER CLUES . . . . . . . 8 Advances in genomics studies have revealed new etiological and somatic genetic events that drive breast cancer pathogenesis. THE POTENTIAL OF PRECISION MEDICINE RESTS IN BRINGING MOLECULAR DIAGNOSTICS TO MARKET . . . . . . . . . . . . . . . . . . . . .12 Breakthroughs in molecular diagnostics, now more than ever, affect the shaping of clinical and personalized medicine. DECIPHERING THE CANCER TRANSCRIPTOME . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 A variety of malignant outliers may hide in transcriptome profiles that emphasize averages. Probing the statistical shadows means conducting singlecell analyses and detecting chimeric RNAs and contextual polymorphisms. Regular Features CASE STUDY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .22 Breast Cancer YAPI (Yet Another Prognostic Indicator) Revisited: American Society of Clinical Oncology Recommendations Use of biomarker assays can guide decision-making processes and standardize clinical approaches for women who have early-stage invasive breast cancer. SNAPSHOT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .24 The Brain-to-Brain Loop in Molecular Oncology Laboratory Testing Various methods allow clinical laboratories to maximize their efficiency and usefulness throughout the entire lab testing process. NEWS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Cover: iStock / Raycat Above (top): iStock / Raycat; (bottom): iStock / YokoDesign www.clinicalomics.com NEW PRODUCTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .21 MEETING ROUNDUP . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .31 April 2016 Clinical OMICs 5 https://twitter.com/ClinicalOMICs https://www.youtube.com/channel/UCXBPPWZv--Ne4NfAUHcc8hg http://www.clinicalomics.com

Table of Contents for the Digital Edition of Clinical OMICs - Volume 3, Issue 4

Contents

Clinical OMICs - Volume 3, Issue 4