EMD Millipore eBook - 5

So Many Ways to Die
Countless Behind-the-Scenes Cell Murders, Suicides,
and Quiet Deaths Contribute to Both Survival
and Disease at the Whole Organism Level

he collection of biochemical processes that
comprise cell death in living organisms is
a compelling area of study not only for cell
biologists, but for biomedical scientists studying
the diversity of cell death in health and disease
processes including aging, cancer, neurodegeneration, and autoimmunity. Accumulation of
damaged cells due to a failure to decommission
and remove them from service can contribute
to significant organismal deficits, deterioration
and disease complications such as those seen in
developmental anomalies, inflammation, and
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neoplasias. Awareness and assessment of the
molecular pathways leading to both helpful
and deleterious cell death are essential to an
understanding of disease processes and development of targets for therapeutic intervention.
Cellular death occurs by a surprising variety
of mechanisms, and our modern understanding
of these pathways bears little resemblance to
historical classifications that were based on
means of digestion or "-phagy", and confirmed
by morphological characteristics. Whether active
or passive, oxidative or apoptotic, a deeper

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EMD Millipore eBook

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