evotec_Nov23_PanOmicsDriven - 16

The PanHunter Platform
EVOTEC'S
PREDICTIVE
TOXICOLOGY
PLATFORM
In the second section of this article, you will discover
how Evotec has combined forces from across its
business areas to address the challenge of toxicology
prediction. Driving this research is Evotec's strong
expertise in cell biology and PanOmics research along
with its state-of-the-art equipment, custom-built
streamlined workflows, and unique ground-breaking
PanHunter bioinformatics platform.
Evotec has been developing PanOmics and
PanHunter as two platforms specifically for:
PanOmics: High-throughput
and cost effective omics data
generation
PanHunter: High-throughput
omics data analysis
Combining PanOmics and PanHunter with our
world-leading pre-clinical safety and toxicology
profiling platform (Cyprotex) is opening new doors
to predictive pharmacology and toxicology.
OUR PROTOCOL STARTS WITH:
Cell lysis in the
assay plate following
the compound
incubation period
mRNA molecules
from the lysate are
captured by the oligo(dT)
primers for reverse
transcription
EVOTEC'S INTEGRATED CUSTOM
SERVICE OFFERING
Transcriptomics is finally entering into
mainstream toxicology, not only for DILI but also
other areas of toxicology such as cardiotoxicity and
nephrotoxicity. Through a custom transcriptomic
service, Evotec can evaluate different organ-specific
models to investigate mechanisms of toxicity and
potential safety liabilities.
Evotec has built vast expertise in all areas
relevant for the complete transcriptomic analysis
workflow:
Advanced cell culture systems for in vitro
toxicology
The most advanced high- throughput
transcriptomics platforms
16
GENengnews.com

https://www.genengnews.com https://www.genengnews.com

evotec_Nov23_PanOmicsDriven

Table of Contents for the Digital Edition of evotec_Nov23_PanOmicsDriven