evotec_Nov23_PanOmicsDriven - 21

PRECISION
MEDICINE
EXPANDS
THE CLINIC'S
BOUNDARIES
Healthcare is becoming less
reactive and more proactive now
that it is taking advantage of
" omics " technologies and secure
data exchange architectures.
By Priya Kalia, PhD
Human genomes are nearly identical from
person to person, but the small degree to which our
genomes differ, about 0.1%, is medically significant.
It contributes to the variability in our susceptibilities
to particular diseases, as well as in our
responses to particular medical treatments, including
treatments such as cancer immunotherapy.
(We might add that in cancer immunotherapy, two
genomes may be relevant: the genome of the patient
and the genome of the tumor.)
Differences at the genomic level and their consequences
are becoming better understood, leading to
a new medical paradigm: precision medicine. Precision
medicine follows a patient-specific tailored
approach. In its consideration of genomic details,
21
GENengnews.com
PLUMMETING SEQUENCING COSTS
Genome sequencing and mass spectrometry
technologies are easing the adoption of " omics "
precision medicine goes beyond traditional medicine's
" one size fits all " approach.
Advances in precision medicine were covered at
the International Precision Medicine Conference,
a virtual event that was held April 19-21. Some of
the experts who participated in the event (or had
been scheduled to do so) also contributed commentary
to this article. Here, the experts discuss precision
medicine applications that involve low-cost
sequencing, metabolomics, regenerative medicine,
or the secure use of patient information.
Precision medicine doesn't necessarily imply that unique treatments are devised for
each patient. Instead, it usually refers to how patient stratification may be refined,
improving assessments of disease risk, predictions of treatment response, yet it still
demands technological progress across a range of disciplines.
[TEK IMAGE/SCIENCE PHOTO LIBRARY/Getty Images]

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evotec_Nov23_PanOmicsDriven

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