evotec_Nov23_PanOmicsDriven - 27

PERSONALIZED
MEDICINE COULD
BE IMPROVED BY
NEW PRECISION
MEDICINE TOOL
Scientists have found that patients with inflammatory
bowel disease (IBD) develop the condition due to distinct and different
mechanisms, determined by their genetics [Kirisa99/Getty Images]
A multi-disciplinary group of systems biologists,
clinicians, immunologists, and microbiologists say
they have developed and tested a systems medicine
workflow that identifies the hidden genetic connections
that form patient-specific patterns, which could guide
better therapy selections. Their study
" A systems genomics approach to uncover patientspecific
pathogenic pathways and proteins in
ulcerative colitis " appears in Nature Communications.
Researchers and clinicians from the Quadram
Institute, the Earlham Institute, the Norfolk and
Norwich University Hospital, and University of East
Anglia, with collaborators in Cambridge, London,
and Leuven, have found that patients with Inflammatory
Bowel Disease (IBD) develop the condition
due to distinct and different mechanisms, determined
by their genetics.
27
GENengnews.com
The team described the use of a novel systems
genomics approach and workflow that identified
which of several possible pathways to disease a
patient has. They expect their findings will lead
to more effective diagnosis and treatments and
provide a much better understanding of this
complicated condition, which can also be applied
to other perplexing disease studies to help more
patients.
" We describe a novel precision medicine
workflow, the integrated single nucleotide polymorphism
network platform (iSNP), designed to determine
the mechanisms by which SNPs affect cellular
regulatory networks, and how SNP co-occurrences
contribute to disease pathogenesis in ulcerative
colitis (UC), " write the investigators.
" Using SNP profiles of 377 UC patients we
mapped the regulatory effects of the SNPs to a

https://www.evotec.com/en https://www.genengnews.com https://www.nature.com/articles/s41467-022-29998-8 https://www.nature.com/articles/s41467-022-29998-8 https://www.nature.com/articles/s41467-022-29998-8 https://www.genengnews.com https://www.genengnews.com

evotec_Nov23_PanOmicsDriven

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