evotec_Nov23_PanOmicsDriven - 3

PanOmics-Driven
Drug Discovery
Next-generation multi-omics approaches
facilitate precision medicine
Compound Cmax DILI in vivo HIAT assay Compound
acetaminophen 147.41 +VE
amiodarone
amitriptyline
amlodipine
atenolol
azathioprine
2.86 +VE
0.43 +VE
0.04 +VE
4.60 +VE
4.48 +VE
benzbromarone 13.96 +VE
bicalutamide
bosentan
bromfenac
carbamazepine
celecoxib
chloroquine
chlorpromazine
citalopram
clomipramine
clozapine
dasatinib
diclofenac
donepezil
erythromycin
fenofibrate
fluoxetine
flutamide
fluvastatin
gefitinib
gemfibrozil
haloperidol
ibuprofen
imatinib
imipramine
indomethacin
irbesartan
isoniazid
ketoconazole
lovastatin
metoclopramide
nefazodone
nifedipine
nimesulide
nitrofurantoin
nortriptyline
Precision
Medicine Marshals
Its Resources
Personalized
Medicine Could
Be Improved by
New Precision
Medicine Tool
o5
27
© GEN Publishing Inc., November, 2023
Transforming
Toxicology
Prediction via
PanOmics
1.96 +VE
6.04 +VE
19.77 +VE
43.24 +VE
2.68 +VE
0.48 +VE
0.90 +VE
0.26 +VE
0.49 +VE
1.77 +VE
0.61 +VE
9.28 +VE
0.11 +VE
7.24 +VE
18.57 +VE
0.28 +VE
4.36 +VE
0.58 +VE
0.21 +VE
185.36 +VE
0.04 +VE
olanzapine
paroxetine
perhexiline
phenformin
pioglitazone
piroxicam
promethazine
rifabutin
risperidone
ritonavir
rosiglitazone
sertraline
simvastatin
sulindac
tamoxifen
302.05 +VE
4.40 +VE
0.50 +VE
7.44 +VE
3.51 +VE
75.74 +VE
12.11 +VE
0.02 +VE
0.40 +VE
3.62 +VE
0.28 +VE
20.07 +VE
15.15 +VE
0.81 +VE
0.08 +VE
0.15 +VE
2.11 +VE
0.63 +ve
3.01 +VE
9.82 +VE
0.28 +VE
0.69 +VE
0.07 +VE
15.00 +VE
1.06 +VE
0.08 +VE
0.02 +VE
24.66 +VE
0.73 +VE
-VE
+VE
-VE
+VE
-VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
-VE
+VE
+VE
+VE
+VE
-VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
-VE
+VE
+VE
-VE
+VE
+VE
+VE
+VE
+VE
-VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
-VE
+VE
+VE
+VE
+VE
+VE
-VE
7.95
troglitazone
verapamil
warfarin
zafirlukast
zimelidine
zomepirac
amikacin
atropine
betaine
brompheniramine
caffeine
chlorpheniramine
dexamethasone
dopamine
droperidol
dutasteride
epinephrine
ergocalciferol
fenoldopam
fexofenadine
flumazenil
folic acid
hydrocortisone
isoproterenol
levocarnitine
liothyronine
loperamide
loratadine
meclizine
minoxidil
nadolol
naloxone
neomycin
oxybutynin
37.65
6.22
0.60
11.08
1.14
0.33
10.53
49.60
0.03
724.55
0.03
56.10
0.69
0.23
dextromethorphan 0.02
dobutamine
1.27
0.14
0.01
0.08
0.00
0.05
0.00
0.57
0.83
1.72
0.77
1.13
isosorbide dinitrate 0.00
kanamycin
59.50
85.70
0.01
0.01
0.07
0.03
1.19
0.61
0.00
0.44
0.02
phenoxybenzamine 0.19
phentolamine
physostigmine
pimozide
pindolol
plerixafor
propantheline
protriptyline
pyridoxine
riboflavin
streptomycin
terazosin
theophylline
thiamine
vinblastine
vitamin c
0.07
0.02
0.11
0.27
1.84
0.44
1.10
0.45
0.69
60.32
0.13
93.27
6.80
0.01
0.09
tolcapone
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+ve
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-ve
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
thioridazine
ticlopidine
Cmax DILI in vivo HIAT assay
0.55
+VE
+VE
+VE
+VE
-VE
+VE
+VE
+VE
+VE
+VE
-VE
+VE
-VE
+VE
+VE
-VE
-VE
+VE
-VE
-VE
+VE
-VE
-VE
-VE
-VE
-VE
+VE
-VE
+VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
+VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
+VE
+VE
+VE
-VE
+VE
-VE
-VE
-VE
-VE
-VE
-VE
+VE
-VE
Compound
acetaminophen
amiodarone
amitriptyline
amlodipine
atenolol
azathioprine
benzbromarone
bicalutamide
bosentan
bromfenac
carbamazepine
celecoxib
chloroquine
chlorpromazine
citalopram
clomipramine
clozapine
dasatinib
diclofenac
donepezil
erythromycin
fenofibrate
fluoxetine
flutamide
fluvastatin
gefitinib
gemfibrozil
haloperidol
ibuprofen
imatinib
imipramine
indomethacin
irbesartan
isoniazid
ketoconazole
lovastatin
metoclopramide
nefazodone
nifedipine
nimesulide
nitrofurantoin
nortriptyline
olanzapine
paroxetine
perhexiline
phenformin
pioglitazone
piroxicam
promethazine
rifabutin
risperidone
ritonavir
rosiglitazone
sertraline
simvastatin
sulindac
tamoxifen
Avg Cmax DILI in vivo Transc & AI Compound
thioridazine
147.41
2.86
0.43
0.04
4.60
4.48
13.96
1.96
6.04
19.77
43.24
2.68
0.48
0.90
0.26
0.49
1.77
0.61
9.28
0.11
7.24
18.57
0.28
4.36
0.58
0.21
185.36
0.04
302.05
4.40
0.50
7.44
3.51
75.74
12.11
0.02
0.40
3.62
0.28
20.07
15.15
0.81
0.08
0.15
2.11
0.63
3.01
9.82
0.28
0.69
0.07
15.00
1.06
0.08
0.02
24.66
0.73
12
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+ve
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
levocarnitine
liothyronine
loperamide
loratadine
+VE meclizine
+VE minoxidil
nadolol
+VE
+VE
+VE
+VE
+VE
-VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
-VE
+VE
+VE
+VE
+VE
+VE
+VE
naloxone
neomycin
oxybutynin
phenoxybenzamine
phentolamine
physostigmine
pimozide
pindolol
plerixafor
propantheline
protriptyline
pyridoxine
riboflavin
streptomycin
terazosin
theophylline
thiamine
vinblastine
vitamin c
59.50
85.70
0.01
0.01
0.07
0.03
1.19
0.61
0.00
0.44
0.02
0.19
0.07
0.02
0.11
0.27
1.84
0.44
1.10
0.45
0.69
60.32
0.13
93.27
6.80
0.01
0.09
PanHunter:
Evotec's nextgeneration
multi-omics
data
analysis platform
-VE
+VE
+VE
+VE
-VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
-VE
+VE
+VE
+VE
+VE
-VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
ticlopidine
tolcapone
troglitazone
verapamil
warfarin
zafirlukast
zimelidine
zomepirac
amikacin
atropine
betaine
brompheniramine
caffeine
chlorpheniramine
dexamethasone
dextromethorphan
dobutamine
dopamine
droperidol
dutasteride
epinephrine
ergocalciferol
fenoldopam
fexofenadine
flumazenil
folic acid
hydrocortisone
isoproterenol
isosorbide dinitrate
kanamycin
Avg Cmax DILI in vivo Transc & AI
0.55
7.95
37.65
6.22
0.60
11.08
1.14
0.33
10.53
49.60
0.03
724.55
0.03
56.10
0.69
0.23
0.02
1.27
0.14
0.01
0.08
0.00
0.05
0.00
0.57
0.83
1.72
0.77
1.13
0.00
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+VE
+ve
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-ve
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
+VE
+VE
+VE
+VE
-VE
+VE
+VE
+VE
+VE
-VE
-VE
+VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
+VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
+VE
-VE
-VE
-VE
+VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
-VE
Precision
Medicine Expands
the Clinic's
Boundaries
21
29
5 Minutes with
Dr John Szilagyi of
Bristol Myers Squibb
on PanHunter
35
evotec_Nov23_PanOmicsDriven

Table of Contents for the Digital Edition of evotec_Nov23_PanOmicsDriven
