GEN-Thermo_Oct22_MakingThePromiseOf - 25

OVERCOMING mRNA PRODUCTION SCALE-UP CHALLENGES
And technologies adopted as a result of COVID-19,
particularly those used make m-RNA vaccines, are
here to stay, points out Kumar, who examined the
impact of the pandemic vaccine manufacturing in a
recent research paper.
Messenger RNA platform-based vaccines
emerged as winners
" Messenger RNA platform-based vaccines have
emerged as a winner partly as a result of smart vaccine
manufacturing technologies. And, in the future, use
of these systems will continue to grow as industry
develops vaccines for a wide range of contagious
diseases, continues Kumar. " These vaccines can be
produced faster, have quick turn-around, are customizable
to specific viruses, and hopefully cheaper. "
His view take is in keeping with a recent survey of
95 vaccine makers by the Coalition for Epidemic
Preparedness Innovations (CEPI), which found that
the majority plan to invest in mRNA and or DNA
vaccine production capacity over the next five years.
For the wider biopharmaceutical industry, particularly
companies not involved in the fight against COVID19,
the move towards smart manufacturing technologies
is likely to be slower according to Kumar, who
says entry barriers remain.
" In the context of the biopharma industry, smart
manufacturing would mean the adoption of smart
devices to capture, store, and transmit data and
services to facilitate connections between devices
during each stage of the vaccine development and
manufacturing process, " he tells GEN.
" However, there are a few barriers that firms usually
face: economic constraints, limitations with technology
infrastructure, ambiguity with the ownership,
privacy, and security of data. These issues need to be
considered. "
Scaling Up Manufacturing
When it's Needed Most...
In about 10 months, Thermo Fisher Scientific
drastically scaled up raw material manufacturing
for mRNA production, leaning on
many decades of experience, to meet both
client and public health needs during the
global SARS-CoV-2 crisis.
Read the Case Study
GENengnews.com | 25

https://www.thermofisher.com/us/en/home.html https://asmedigitalcollection.asme.org/computingengineering/article-abstract/22/4/040903/1129387/Smart-Vaccine-Manufacturing-Using-Novel?redirectedFrom=fulltext https://cepi.net/news_cepi/vaccine-production-efforts-across-key-regions-mapped-in-first-of-its-kind-study-to-prepare-for-future-pandemics/ http://assets.thermofisher.com/TFS-Assets/BID/Reference-Materials/scaling-manufacturing-when-needed-most-case-study.pdf?cid=bid_nat_mrw_r01_co_cp1531_pjt9473_ext3856_0db_gbn_eb_tls_an_s00_ https://www.genengnews.com

GEN-Thermo_Oct22_MakingThePromiseOf

Table of Contents for the Digital Edition of GEN-Thermo_Oct22_MakingThePromiseOf