GEN-Thermo_Oct22_MakingThePromiseOf - 33

OVERCOMING mRNA PRODUCTION SCALE-UP CHALLENGES
Optimize Impurity Analysis with Ease
Determine the most suitable conditions for the detection of posttranscriptional
impurities with a time-effective scouting approach
* High selectivity and separation of mRNA impurities using Thermo Scientific™ DNAPac™ RP
HPLC columns and Thermo Scientific™ DNAPac™ PA 200RS HPLC columns.
* Fast method optimization through simultaneous scouting of columns with different chemistries
on Thermo Scientific™ Vanquish™ Duo for Dual LC system.
Reversed phase
mRNA
Solvent valve right
A1
A2
A3
A4
A5
A6
A7
A8
A9
A10
A1
A2
A3
A4
A5
Solvent valve left
A6
A7
A8
A9
A10
Impurities
Non-purified mRNA
Purified mRNA
Minutes
Flow scheme overview: Thermo Scientific Vanquish Duo for Dual LC
with Solvent Extension Kits for automated method scouting. Dual
pump and dual column compartment set-up.
Ion exchange
mRNA
Impurities
View complete
application note
Thermo Scientific™
DNAPac™ RP HPLC Columns
Thermo Scientific™ DNAPac™ PA200
Oligonucleotide HPLC Columns
Vanquish Flex 300
32.25 H x 21.65 W
Thermo Scientific™
Vanquish™ Duo HPLC System
33
Acclaim C18 Column
nPac Columns
Dionex IonPac Columns
Acclaim C18 Column
mAU
https://www.thermofisher.com/us/en/home.html https://assets.thermofisher.com/TFS-Assets/CMD/Application-Notes/an-000471-hplc-vanquish-duo-mRNA-method-development-an000471-na-en.pdf https://www.thermofisher.com/order/catalog/product/088923 https://www.thermofisher.com/order/catalog/product/VQDUO-INVERSE https://www.thermofisher.com/order/catalog/product/082509 https://www.thermofisher.com/order/catalog/product/082509

GEN-Thermo_Oct22_MakingThePromiseOf

Table of Contents for the Digital Edition of GEN-Thermo_Oct22_MakingThePromiseOf

Contents
GEN-Thermo_Oct22_MakingThePromiseOf - Cover1
GEN-Thermo_Oct22_MakingThePromiseOf - Cover2
GEN-Thermo_Oct22_MakingThePromiseOf - Contents
GEN-Thermo_Oct22_MakingThePromiseOf - 4
GEN-Thermo_Oct22_MakingThePromiseOf - 5
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GEN-Thermo_Oct22_MakingThePromiseOf - Cover3
GEN-Thermo_Oct22_MakingThePromiseOf - Cover4
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