Immuno-Oncology Advances in Applied Cellular Analysis - 11

Blocking Cancer Signaling
Leads to

Discovery of New
Tumor-Promoting Pathway

11

| GENengnews.com

"Since we were genetically deleting the
ERK1/2 pathway, we expected to see less cell
proliferation," explained co-lead study author
Petrus R. de Jong, M.D., Ph.D., translational
scientist at Sanford Burnham Prebys Medical
Discovery Institute. "Instead, the opposite
occurred. There was more cell growth and
loss of organization within the cells."
The exciting part of this new study is investigators found that treating both ERK1/2 and
the compensatory pathway ERK5 concomitantly with a combination of drug inhibitors

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A

n international research team lead by
scientists at the University of California
San Diego (UCSD) School of Medicine
uncovered some surprising results while
investigating a potential therapeutic target
for the ERK1 and two pathways. These
signaling pathways are widely expressed and
known to drive cancer growth in one-third
of patients with colorectal cancer (CRC). The
UCSD team found that an alternative pathway
immediately emerges when ERK1/2 is halted,
thus allowing tumor cell proliferation to
continue.


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Immuno-Oncology Advances in Applied Cellular Analysis

Table of Contents for the Digital Edition of Immuno-Oncology Advances in Applied Cellular Analysis

Contents
Immuno-Oncology Advances in Applied Cellular Analysis - 1
Immuno-Oncology Advances in Applied Cellular Analysis - 2
Immuno-Oncology Advances in Applied Cellular Analysis - 3
Immuno-Oncology Advances in Applied Cellular Analysis - Contents
Immuno-Oncology Advances in Applied Cellular Analysis - 5
Immuno-Oncology Advances in Applied Cellular Analysis - 6
Immuno-Oncology Advances in Applied Cellular Analysis - 7
Immuno-Oncology Advances in Applied Cellular Analysis - 8
Immuno-Oncology Advances in Applied Cellular Analysis - 9
Immuno-Oncology Advances in Applied Cellular Analysis - 10
Immuno-Oncology Advances in Applied Cellular Analysis - 11
Immuno-Oncology Advances in Applied Cellular Analysis - 12
Immuno-Oncology Advances in Applied Cellular Analysis - 13
Immuno-Oncology Advances in Applied Cellular Analysis - 14
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