Immuno-Oncology Advances in Applied Cellular Analysis - 17

Continuous Live-Cell
Analysis of the
Immune-Tumor Axis
Driving Biological Insight and Productivity with
Real-Time Non-Invasive Phenotype Assays

17

| GENengnews.com

In vitro cell-based assays are critical for probing these mechanisms and evaluating new
potential treatments. Cell activation, proliferation, and vitality (health, death, apoptosis,
etc.) measurements are of high interest to
immuno-oncology researchers, and co-culture assays for killing, engulfment, and clearance of tumor cells by immune cells are commonly used. Other examples include models
for tumor metastasis and T-cell homing using
cell migration, invasion, and chemotaxis
assays. Traditionally these assays are
conducted using plate-reader biochemical

ADDITIONAL CONTENT

Guide
How Live-Cell Analysis Can Benefit
Your Existing Research Workflows
Learn how live-cell analysis facilitates research including:
* Time-dependent processes such as antibody uptake
* Assessing cell viability during treatments or immune cell killing
* Optimizing work with sensitive cell line such as iPSC neurons

Download Now

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I

n recent years, impressive progress has
been made in our understanding of the
basic mechanisms of immune and cancer cell
biology. Indeed, this knowledge has translated to true benefits for cancer patients via
novel immunotherapies such as checkpoint
inhibitor drugs (e.g., ipilimumab (CTLA4),
nivolumab (PD-1)) and adoptive T-cell
transfer protocols.1 Despite this, the myriad
complexity and dynamic nature of the
interplay between the immune and
cancer systems leaves many unanswered
questions.

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Immuno-Oncology Advances in Applied Cellular Analysis

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