Immuno-Oncology Advances in Applied Cellular Analysis - 6

Advances in Applied Cellular Analysis * PD-L1 Mutations and Immunotherapy Resistance

study author Keisuke Kataoka, M.D., Ph.D., assistant
professor in the Department of Pathology and Tumor
Biology at Kyoto University. "Our study suggests that
whether or not a cancer has this particular abnormality
could be a good indicator of its response to
immune checkpoint inhibitor drugs."
The findings from this study were published recently in
Nature in an article entitled "Aberrant PD-L1 Expression
Through 3'-UTR Disruption in Multiple Cancers."

Antibodies that target PD-L1 or
its receptor PD-1 have shown
extraordinary therapeutic
effects for many cancer
patients-even for those who
are terminally ill.

6

| GENengnews.com

Japanese scientists have found unique genetic alterations that could indicate whether expensive
immune checkpoint inhibitors would be effective for a particular patient. Publishing in Nature, the
study reports that genetic alterations affecting a part of the PD-L1 gene increase the production of
the protein, allowing cancer cells to escape detection by the immune system. Kyoto University


http://www.GENengnews.com

Immuno-Oncology Advances in Applied Cellular Analysis

Table of Contents for the Digital Edition of Immuno-Oncology Advances in Applied Cellular Analysis

Contents
Immuno-Oncology Advances in Applied Cellular Analysis - 1
Immuno-Oncology Advances in Applied Cellular Analysis - 2
Immuno-Oncology Advances in Applied Cellular Analysis - 3
Immuno-Oncology Advances in Applied Cellular Analysis - Contents
Immuno-Oncology Advances in Applied Cellular Analysis - 5
Immuno-Oncology Advances in Applied Cellular Analysis - 6
Immuno-Oncology Advances in Applied Cellular Analysis - 7
Immuno-Oncology Advances in Applied Cellular Analysis - 8
Immuno-Oncology Advances in Applied Cellular Analysis - 9
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