GEN-IsoPlexis_RT_Nov22_Single-CellAdvances - 2

ROUND T ABLE
Single-Cell Advances in Functional
Immune Monitoring for Developing
Immune Therapies and Uncovering
Disease Pathogenesis
Unlike many other therapeutic approaches, treatments that harness the immune system have
the potential to not just treat but cure a disease, including those that historically have poor
clinical outcomes. However, because the immune system is dynamic and complex, developing
immunotherapies can be a daunting task.
Different immune cells in various trajectories of their life spans perform critical functions at
different points in time. Single-cell functional proteomics plays a pivotal role in the drug
development process by revealing insights that cannot be identified by bulk immunoassays
and by homing in on the highly polyfunctional cells that are driving in vivo biology.
The drug discovery and development process is hampered by challenges to understanding
the complexities of the immune system. As our experts will show in this perspective, singlecell
functional proteomics is becoming the tool of choice to unravel the intricacies of immune
function and advance the development of future life-saving medicines.
GEN spoke to three thought leaders working on immune therapies to hear their views and
strategies on using single-cell functional proteomics in their quest to treat some of the world's
most devastating diseases.
2 | GENengnews.com
© GEN Publishing, October 2022
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GEN-IsoPlexis_RT_Nov22_Single-CellAdvances

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