PHCbi-Panasonic eBook - 13

Cell Therapy Today * New Developments in Immunotherapy * Benefits of Oxygen Control in the Cell Culture Incubator

Coupled with both active and passive contamination mitigation, along with a range of
decontamination options to meet FDA criteria,
the focus of contemporary cell culture research
continues to narrow on cell specificity.
n
References
1. Mohyeldin, Ahmed, Tomás Garzón-Muvdi, and Alfredo
Quiñones- Hinojosa. "Oxygen in Stem Cell Biology: A Critical
Component of the Stem Cell Niche." Cell Stem Cell 7, no. 2
(2010): 150-61. doi:10.1016/j. stem.2010.07.007.

9. Forristal CE, Wright KL, Hanley NA, Oreffo ROC, Houghton
FD. "Hypoxia inducible factors regulate pluripotency and
proliferation in human embryonic stem cells cultured at
reduced oxygen tensions." Reproduction (2010) 139: 85-97

10. Brahimi-Horn, et al.
11. Ventura-Juncá, Patricio, Isabel Irarrázaval, Augusto J.
Rolle, Juan I. Gutiérrez, Ricardo D. Moreno, and Manuel J.
Santos. "In vitro Fertilization (IVF) in Mammals: Epigenetic and
Developmental Alterations. Scientific and Bioethical Implications for IVF in Humans." Biol Res 48, no. 1 (2015). doi:10.1186/
s40659-015-0059-y.

12. Atkuri, K. R., L. A. Herzenberg, A.-K. Niemi, T. Cowan, and

ability in Embryonic Development and Stem Cell Function." Nat
Rev Mol Cell Biol 9, no. 4 (2008): 285-96. doi:10.1038/nrm2354.

L. A. Herzenberg. "Importance of Culturing Primary Lymphocytes at Physiological Oxygen Levels." Proceedings of the
National Academy of Sciences 104, no. 11 (January 05, 2007):
4547-552. doi:10.1073/pnas.06117 32104.

3. Ibid.

13. Peng ZF, Shi SL, Jin HX, Yao GD, Wang EY, Yang HY, Song

2. Simon, M. Celeste, and Brian Keith. "The Role of Oxygen Avail-

4. Mohyeldin, et al.
5. Table 2. Graphic adapted from McKeown, S R, MA, PhD.
"Defining Normoxia, Physoxia and Hypoxia in Tumours-
implications for Treatment Response." Br J Radiol, 20130676th
ser., 87, no. 1035 (March 2014). doi:10.1259/bjr.20130676.

WY, and Sun YP. "Impact of Oxygen Concentrations on Fertilization, Cleavage, Implantation, and Pregnancy Rates of in
vitro Generated Human Embryos." International Journal of
Clinical and Experimental Medicine, 6179-85, 8, no. 4 (2015).
US National Library of Medicine National Institutes of Health.

15. Ventura-Junca et. al.

7. Herzenberg, Leonore A., and Leonard A. Herzenberg.
"Our NIH Years: A Confluence of Beginnings." The Journal of
Biological Chemistry 288, no. 1 (January 4, 2013): 687-702.
doi:10.1074/jbc.X112.426742.

16. Table 3. Graphic adapted from McKeown, S R, MA, PhD.

8. Brahimi-Horn, M. C., and J. Pouyssegur. "HIF at a

"Defining Normoxia, Physoxia and Hypoxia in Tumours-
implications for Treatment Response."
Br J Radiol, 20130676th ser., 87, no. 1035 (March 2014).
doi:10.1259/bjr.20130676.

Glance." Journal of Cell Science 122, no. 8 (2009): 1055-057.
doi:10.1242/jcs.035022.

Antioxidants, and the Degenerative Diseases of Aging."

| GENengnews.com

18. Wang, Fangnian, Shoba Thirumangalathu, and Mary R.
Loeken. "Establishment of New Mouse Embryonic Stem Cell
Lines Is Improved by Physiological Glucose and Oxygen."
Cloning and Stem Cells 8, no. 2 (2006): 108-16. doi:10.1089/
clo.2006.8.108.

19. Simon et al.
20. Ibid.
21. Tiede, L. M., E. A. Cook, B. Morsey, and H. S. Fox. "Oxygen
Matters: Tissue Culture Oxygen Levels Affect Mitochondrial Function and Structure as Well as Responses to HIV
Viroproteins." Cell Death Dis 2, no. 12 (2011). doi:10.1038/
cddis.2011.128.

23. Simon et al.
24. Restelli, L., C. Guarneri, A. Paffoni, A. Mangiarini, G. Ragni,
and E. Somigliana. "Can We Use Incubators with Atmospheric
Oxygen Tension in the First Phase of in vitro Fertilization? A
Retrospective Analysis." Fertility and Sterility 100, no. 3 (2013).
doi:10.1016/j.fertn- stert.2013.07.282.

14. Simon et al.

6. Simon, et al.

13

Proceedings of the National Academy of Sciences 90, no. 17
(1993): 7915-922. doi:10.1073/ pnas.90.17.7915.

17. Ames, B. N., M. K. Shigenaga, and T. M. Hagen. "Oxidants,

White Paper Note Citation:
Radosevich, Carl. Benefits of Oxygen Control in the Cell
Culture Incubator. Wood Dale, IL: PHC Corporation of
North America, 2016.
http://www.GENengnews.com
PHCbi-Panasonic eBook

Table of Contents for the Digital Edition of PHCbi-Panasonic eBook
