PHCbi-Panasonic eBook - 14

Immuno-Oncology
Enhances Battlespace
Awareness
Molecular Imaging Could Help Clinicians Accurately
Select Patients for Treatment or Monitoring
Ashley Jean Yeager

Although cancer cells are derived from normal
tissues, they harbor DNA mutations that often
result in tumor-specific molecules that can
14

| GENengnews.com

Scientists are now developing therapeutics
to target the pathways that help cancer cells
evade an immune response. From inhibiting
key checkpoints that regulate immune activity,
to developing new chimeric antigen receptor

ADDITIONAL CONTENT

Feature Note
Maintain optimal in vitro conditions to preserve
cells for downstream studies and improve
reproducibility of results.
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MOLEKUUL/Science Photo Library/Getty Images

T

he immune system has two fundamental
(and contrasting) jobs: spare normal cells
(which carry self-antigens) and attack pathogenic cells (which carry nonself-antigens).
Somewhere between normal cells and
exogenous pathogens are cancer cells.

induce an immune response. Still, cancer cells
often evade immune surveillance, as demonstrated by cancers that develop to the point
of being clinically recognized, notes Lance
Leopold, M.D., the group vice president for
immuno-oncology development at Incyte.

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PHCbi-Panasonic eBook

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